Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface

doi:10.1002/anie.201309974

CORC > 化学研究所 > 中国科学院化学研究所

	Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface
	Yang, Gao 1,2; Cao, Yanhua 1; Fan, Junbing 1; Liu, Hongliang 1; Zhang, Feilong 1,2; Zhang, Pengchao 1,2; Huang, Chao 1; Jiang, Lei 1; Wang, Shutao 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2014-03-10
卷号	53 期号:11 页码:2915-2918
关键词	Cell Gradients Chemical Modification Nanotopographic Gradient Topographic Interaction
ISSN号	1433-7851
DOI	10.1002/anie.201309974
英文摘要	The control of cell gradients is critical for understanding many biological systems and realizing the unique functionality of biomimetic implants. Herein, we report a nanotopographic gradient strategy that can rapidly generate cell gradients on a nanodendritic silica substrate without any chemical modification. We can achieve controllable cell gradients within only half an hour of cell incubation solely induced by the topographic effect of the gradient nanodendrites. We also demonstrate that cell gradients can be modulated by the combination of nanotopographic and chemical gradients. The results reveal that the enhanced topographic interactions between the nanodentritic structure and nanoscaled filopodia of the cells mainly contribute to the generation of cell gradients.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000336846300009
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51501]
专题	中国科学院化学研究所
通讯作者	Wang, Shutao
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Gao,Cao, Yanhua,Fan, Junbing,et al. Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(11):2915-2918.
APA	Yang, Gao.,Cao, Yanhua.,Fan, Junbing.,Liu, Hongliang.,Zhang, Feilong.,...&Wang, Shutao.(2014).Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(11),2915-2918.
MLA	Yang, Gao,et al."Rapid Generation of Cell Gradients by Utilizing Solely Nanotopographic Interactions on a Bio-Inert Glass Surface".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.11(2014):2915-2918.