Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry

doi:10.1039/c3ra46934d

CORC > 化学研究所 > 中国科学院化学研究所

	Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry
	Hu, Yu 1,2; Jin, Jing 1; Han, Yuanyuan 1; Yin, Jinghua 1; Jiang, Wei 1; Liang, Haojun 3
刊名	RSC ADVANCES
	2014
卷号	4 期号:15 页码:7716-7724
ISSN号	2046-2069
DOI	10.1039/c3ra46934d
英文摘要	Protein adsorption behavior is a key factor that determines whether materials can be used as medical polymer materials. In this study, fibrinogen (Fib) adsorptions on three different poly(ethylene glycol) (PEG) surfaces that differed in chain length and chain density were investigated using a quartz crystal microbalance with dissipation (QCM-D) and a dual polarization interferometry (DPI) with respect to adsorbed masses, viscoelastic properties and chain conformations. On QCM-D chips, PEG chains were tight and in extended brush conformations. Meanwhile, on DPI chips, PEG(1000) and PEG(2000) may have the same pancake-like conformations, but PEG(5000) had a mushroom conformation. Moreover, several bare spaces were observed on the loose pancake-like PEG(1000)- and PEG(2000)-modified DPI surfaces. Fib could fully spread on the relatively dense PEG(1000)-modified DPI surface and partly spread and tightly orient on the relatively sparse PEG(2000)-modified DPI surface. Thus, grafting density was found to have greater significance in determining Fib adsorption resistance due to its influence on Fib spreading when the chain conformations of hydrophilic molecules were loose pancake-like structures. Furthermore, brush and mushroom structured PEG(5000) chains both had high deformation capacity, which excellently resisted protein adsorption by adjusting their conformation to decrease interaction with Fib. Therefore, the Fib adsorption resistance of PEG-modified surface depended on the grafting density of PEG layer and the deformation capacity of the PEG chain.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000330241000052
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51275]
专题	中国科学院化学研究所
通讯作者	Jiang, Wei
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Dept Polymer Sci & Engn, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Hu, Yu,Jin, Jing,Han, Yuanyuan,et al. Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry[J]. RSC ADVANCES,2014,4(15):7716-7724.
APA	Hu, Yu,Jin, Jing,Han, Yuanyuan,Yin, Jinghua,Jiang, Wei,&Liang, Haojun.(2014).Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry.RSC ADVANCES,4(15),7716-7724.
MLA	Hu, Yu,et al."Study of fibrinogen adsorption on poly(ethylene glycol)-modified surfaces using a quartz crystal microbalance with dissipation and a dual polarization interferometry".RSC ADVANCES 4.15(2014):7716-7724.