Liposomes Physically Coated with Peptides: Preparation and Characterization

doi:10.1021/la501296r

CORC > 化学研究所 > 中国科学院化学研究所

	Liposomes Physically Coated with Peptides: Preparation and Characterization
	Su, Cuicui 1,2; Xia, Yuqiong 3; Sun, Jianbo 1,2; Wang, Nan 1,2; Zhu, Lin 1,2; Chen, Tao 4; Huang, Yanyi 4; Liang, Dehai 1,2
刊名	LANGMUIR
	2014-06-03
卷号	30 期号:21 页码:6219-6227
ISSN号	0743-7463
DOI	10.1021/la501296r
英文摘要	Physically coating liposomes with peptides of desirable functions is an economic, versatile, and less time-consuming approach to prepare drug delivery vehicles. In this work, we designed three peptides-Ac-WWICKKGGNNN-NH2 (W2K3), Ac-WWR-RRGGNNN-NH2(W2R3), Ac-WWGGGGGNNN-NH2(W2G3)-and studied their coating ability on negatively charged liposomes. It was found that the coating was mainly driven by the electrostatic interaction between the peptides' cationic side groups and the acidic lipids, which also mediated the "anchoring" of Trp residuals in the interfacial region of lipid bilayers. At the same conditions, the amount of the coated W2R3 was more than that of W2K3, but the stability of the liposome coated with W2R3 was deteriorated. This was caused by the delocalized charge of the guanidinium group of arginine. The coating of the peptide rendered the liposome pH-responsive behavior but did not prominently change the phase transition temperature. The liposome coated with peptides displayed appropriate pH/temperature dual responsive characteristics and was able to release the content in a controlled manner.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000336952800027
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/51015]
专题	中国科学院化学研究所
通讯作者	Liang, Dehai
作者单位	1.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Minist Educ, Key Lab Polymer Chem & Phys, Beijing 100871, Peoples R China 3.Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shanxi, Peoples R China 4.Peking Univ, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Su, Cuicui,Xia, Yuqiong,Sun, Jianbo,et al. Liposomes Physically Coated with Peptides: Preparation and Characterization[J]. LANGMUIR,2014,30(21):6219-6227.
APA	Su, Cuicui.,Xia, Yuqiong.,Sun, Jianbo.,Wang, Nan.,Zhu, Lin.,...&Liang, Dehai.(2014).Liposomes Physically Coated with Peptides: Preparation and Characterization.LANGMUIR,30(21),6219-6227.
MLA	Su, Cuicui,et al."Liposomes Physically Coated with Peptides: Preparation and Characterization".LANGMUIR 30.21(2014):6219-6227.