DNA-Grafted Polypeptide Molecular Bottlebrush Prepared via Ring-Opening Polymerization and Click Chemistry

doi:10.1021/ma302233m

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	DNA-Grafted Polypeptide Molecular Bottlebrush Prepared via Ring-Opening Polymerization and Click Chemistry
	Chen, Ping 2; Li, Chuang 1; Liu, Dongsheng 1; Li, Zhibo 2
刊名	MACROMOLECULES
	2012-12-25
卷号	45 期号:24 页码:9579-9584
ISSN号	0024-9297
DOI	10.1021/ma302233m
英文摘要	A new type of DNA grafted polypeptide molecular brush was synthesized via a combination of ring-opening polymerization (ROP) and click chemistry. This conjugation method provides an easy and efficient approach to obtain a hybrid DNA-grafted polypeptide molecular bottlebrush. The structure and assembly behaviors of this hybrid brush were investigated using electrophoresis, UV-vis spectroscopy, transmission electron microscopy (TEM), and atomic force microscopy (AFM). Hierarchical supramolecular assemblies can be obtained through hybridization of two kinds of polypeptide-g-DNA molecular bottlebrushes containing complementary DNA side chains. We further demonstrated that such polypeptide-g-DNA can be hybridized with ds-DNA and DNA-grafted gold nanoparticles to form a supermolecular bottlebrush and hybrid bottlebrush, respectively. In addition, DNA-polypeptide hydrogel can be prepared by hybridization of polypeptide-g-DNA with a linker-ds-DNA, which contains the complementary "sticky ends" to serve as cross-linkers.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000312563900003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/48663]
专题	中国科学院化学研究所
通讯作者	Liu, Dongsheng
作者单位	1.Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Minist Educ, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Chen, Ping,Li, Chuang,Liu, Dongsheng,et al. DNA-Grafted Polypeptide Molecular Bottlebrush Prepared via Ring-Opening Polymerization and Click Chemistry[J]. MACROMOLECULES,2012,45(24):9579-9584.
APA	Chen, Ping,Li, Chuang,Liu, Dongsheng,&Li, Zhibo.(2012).DNA-Grafted Polypeptide Molecular Bottlebrush Prepared via Ring-Opening Polymerization and Click Chemistry.MACROMOLECULES,45(24),9579-9584.
MLA	Chen, Ping,et al."DNA-Grafted Polypeptide Molecular Bottlebrush Prepared via Ring-Opening Polymerization and Click Chemistry".MACROMOLECULES 45.24(2012):9579-9584.