Total Synthesis of Sinensilactam A | |
Shao, Wenbin1; Huang, Jun1; Guo, Kai1; Gong, Jianxian1; Yang, Zhen1,2,3,4 | |
刊名 | ORGANIC LETTERS |
2018-04-06 | |
卷号 | 20期号:7页码:1857-1860 |
ISSN号 | 1523-7060 |
DOI | 10.1021/acs.orglett.8b00380 |
英文摘要 | The total synthesis of naturally occurring (+/-)-sinensilactam A was achieved in 18 steps. The key steps of this work are a rhodium-catalyzed [3 + 2] cydoaddition for construction of the two all-carbon vicinal quaternary centers and a convergent and tandem condensation of the in situ generated N-acyliminium intermediate with aldehyde 20. This enabled implementation of a unified strategy for stereoselective formation; of the tetracyclic hemiaminal core of sinensilactam A in a later stage. The total syntheses of applanatumol F and C8-epi-applanatumol D are also achieved using this strategy. |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000429886900039 |
内容类型 | 期刊论文 |
源URL | [http://ir.iccas.ac.cn/handle/121111/46129] |
专题 | 中国科学院化学研究所 |
通讯作者 | Gong, Jianxian; Yang, Zhen |
作者单位 | 1.Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China 2.Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China 3.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China 4.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China |
推荐引用方式 GB/T 7714 | Shao, Wenbin,Huang, Jun,Guo, Kai,et al. Total Synthesis of Sinensilactam A[J]. ORGANIC LETTERS,2018,20(7):1857-1860. |
APA | Shao, Wenbin,Huang, Jun,Guo, Kai,Gong, Jianxian,&Yang, Zhen.(2018).Total Synthesis of Sinensilactam A.ORGANIC LETTERS,20(7),1857-1860. |
MLA | Shao, Wenbin,et al."Total Synthesis of Sinensilactam A".ORGANIC LETTERS 20.7(2018):1857-1860. |
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