Ovalbumin-stabilized gold nanoclusters with ascorbic acid as reducing agent for detection of serum copper

doi:10.1016/j.cclet.2017.10.014

CORC > 化学研究所 > 中国科学院化学研究所

	Ovalbumin-stabilized gold nanoclusters with ascorbic acid as reducing agent for detection of serum copper
	Chen, Yifan 1,3; Qiao, Juan 1,2; Liu, Qianrong 1,4; Qi, Li 1,2
刊名	CHINESE CHEMICAL LETTERS
	2018-03-01
卷号	29 期号:3 页码:366-370
关键词	Ovalbumin-stabilized Gold Nanoclusters Fluorescent Probe Ascorbic Acid Reducing Agent Serum Copper
ISSN号	1001-8417
DOI	10.1016/j.cclet.2017.10.014
英文摘要	Ovalbumin-stabilized gold nanoclusters (OVA@AuNCs) were prepared with-ascorbic acid as a reducing agent. This strategy could realize the synthesis of water-soluble OVA@AuNCs within 20 min. The as prepared fluorescent probe showed a red fluorescence emission at 630 nm. Moreover, the properties of the OVA@AuNCs were characterized by transmission electron microscope, dynamic light scattering, ultraviolet-visible spectroscopy, fluorescent spectroscopy. Based on the surface electron density decrease-induced fluorescence quenching mechanism, the OVA@AuNCs provided high sensitivity and selectivity for sensing copper ions. A good linear relationship was obtained between the fluorescence intensity of OVA@AuNCs and the concentration of copper ions in the range of 5.0-100.0 mu mol/L (R-2=0.999) with a detection limit of 640 nmol/L. Furthermore, the rat serum copper contents were determined by using the OVA@AuNCs based assay, indicating great potential of fluorescent probes for application in biological and clinical analysis. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000429392800006
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45999]
专题	中国科学院化学研究所
通讯作者	Qi, Li
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jilin Univ, Zhuhai Coll, Zhuhai 519041, Peoples R China 4.Xian Univ Sci & Technol, Xian 710054, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yifan,Qiao, Juan,Liu, Qianrong,et al. Ovalbumin-stabilized gold nanoclusters with ascorbic acid as reducing agent for detection of serum copper[J]. CHINESE CHEMICAL LETTERS,2018,29(3):366-370.
APA	Chen, Yifan,Qiao, Juan,Liu, Qianrong,&Qi, Li.(2018).Ovalbumin-stabilized gold nanoclusters with ascorbic acid as reducing agent for detection of serum copper.CHINESE CHEMICAL LETTERS,29(3),366-370.
MLA	Chen, Yifan,et al."Ovalbumin-stabilized gold nanoclusters with ascorbic acid as reducing agent for detection of serum copper".CHINESE CHEMICAL LETTERS 29.3(2018):366-370.