Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer

doi:10.1002/adma.201706220

CORC > 化学研究所 > 中国科学院化学研究所

	Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer
	Cong, Yuwei 1,2; Xiao, Haihua 1,2; Xiong, Hejian 1; Wang, Zigui 1,3; Ding, Jianxun 4; Li, Chan 5,6; Chen, Xuesi 4; Liang, Xing-Jie 5,6; Zhou, Dongfang 1; Huang, Yubin 1
刊名	ADVANCED MATERIALS
	2018-03-15
卷号	30 期号:11
关键词	Computer Tomography Drug Delivery Nanomedicine Shattering Polymers
ISSN号	0935-9648
DOI	10.1002/adma.201706220
英文摘要	Most of the current nanoparticle-based therapeutics worldwide failing in clinical trials face three major challenges: (i) lack of an optimum drug delivery platform with precise composition, (ii) lack of a method of directly monitoring the fate of a specific drug rather than using any other labelling molecules as a compromise, and (iii) lack of reliable cancer models with high fidelity for drug screen and evaluation. Here, starting from a PP2A inhibitor demethylcantharidin (DMC) and cisplatin, the design of a dual sensitive dual drug backboned shattering polymer (DDBSP) with exact composition at a fixed DMC/Pt ratio for precise nanomedicine is shown. DDBSP self-assembled nanoparticle (DD-NP) can be triggered intracellularly to break down in a chain-shattering manner to release the dual drugs payload. Moreover, DD-NP with extremely high Pt heavy metal content in the polymer chain can directly track the drug itself via Pt-based drug-mediated computer tomography and ICP-MS both in vitro and in vivo. Finally, DD-NP is used to eradicate the tumor burden on a high-fidelity patient-derived lung cancer model for the first time.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000427111300022
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45845]
专题	中国科学院化学研究所
通讯作者	Chen, Xuesi; Liang, Xing-Jie; Zhou, Dongfang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 4.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Lab Controllable Nanopharmaceut, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cong, Yuwei,Xiao, Haihua,Xiong, Hejian,et al. Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer[J]. ADVANCED MATERIALS,2018,30(11).
APA	Cong, Yuwei.,Xiao, Haihua.,Xiong, Hejian.,Wang, Zigui.,Ding, Jianxun.,...&Huang, Yubin.(2018).Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer.ADVANCED MATERIALS,30(11).
MLA	Cong, Yuwei,et al."Dual Drug Backboned Shattering Polymeric Theranostic Nanomedicine for Synergistic Eradication of Patient-Derived Lung Cancer".ADVANCED MATERIALS 30.11(2018).