Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release

doi:10.1021/acsami.8b00194

CORC > 化学研究所 > 中国科学院化学研究所

	Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release
	He, Haozhe 1,2; Zhou, Junli 2,3; Liu, Yingjie 2,3; Liu, Shi 2; Xie, Zhigang 2; Yu, Meng 1; Wang, Yong 1; Shuai, Xintao 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018-02-28
卷号	10 期号:8 页码:7413-7421
关键词	Poly(Ether Amine) Morphology Transition Nir-controlled Release Drug Delivery Chemo-photothermal Therapy
ISSN号	1944-8244
DOI	10.1021/acsami.8b00194
英文摘要	Near-infrared (NIR)-light-controlled drug release has aroused great interest because of its advantages in spatiotemporal control. Herein, a photothermally induced morphology transition of the nanoparticles (NPs) for supersensitive drug release has been demonstrated. Doxorubicin (DOX)- and cyanine (Cy)-coloaded thermosensitive poly(ether amine) NPs (DOX&Cy@PEA81) were developed. Because of the photothermal activity of Cy upon irradiation, increase in temperature at the tumor site results, which would be used not only for photothermal therapy but also to spur the release of DOX from the NPs for tunable chemotherapy. The NIR-laser-driven DOX release was validated by a series of intracellular and in vivo experiments on animals. Meanwhile, the chemo-photothermal combinatorial therapy results in optimal cytotoxicity and tumor inhibition. This article provides a promising approach to realizing supersensitive drug release and synergistic chemo-photothermal therapy for cancer.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000426618000070
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45767]
专题	中国科学院化学研究所
通讯作者	Xie, Zhigang; Shuai, Xintao
作者单位	1.Sun Yat Sen Univ, PCFM Lab, Minist Educ, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	He, Haozhe,Zhou, Junli,Liu, Yingjie,et al. Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(8):7413-7421.
APA	He, Haozhe.,Zhou, Junli.,Liu, Yingjie.,Liu, Shi.,Xie, Zhigang.,...&Shuai, Xintao.(2018).Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release.ACS APPLIED MATERIALS & INTERFACES,10(8),7413-7421.
MLA	He, Haozhe,et al."Near-Infrared-Light-Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release".ACS APPLIED MATERIALS & INTERFACES 10.8(2018):7413-7421.