Quantitative single-molecule study of TGF-beta/Smad signaling

doi:10.1093/abbs/gmx121

CORC > 化学研究所 > 中国科学院化学研究所

	Quantitative single-molecule study of TGF-beta/Smad signaling
	Zhao, Rong 1,2; Li, Nan 1,2; Xu, Jiachao 1,2; Li, Wenhui 1,2; Fang, Xiaohong 1,2
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2018
卷号	50 期号:1 页码:51-59
关键词	Single-molecule Imaging And Tracking Single-molecule Force Spectroscopy Tgf-beta/smad Signaling Pathway Quantitative Analysis
ISSN号	1672-9145
DOI	10.1093/abbs/gmx121
英文摘要	TGF-beta/Smad signaling pathway triggers diverse cellular responses among different cell types and environmental conditions. Quantitative analysis of protein-protein interactions involved in TGF-beta/Smad signaling is demanded for understanding the molecular mechanism of this signaling pathway. Live-cell single-molecule microcopy with high spatiotemporal resolution is a new tool to monitor key molecular events in a real-time manner. In this review, we mainly presented the recent work on the quantitative characterization of TGF-beta/Smad signaling proteins by single-molecule method, and showed how it enabled us to obtain new insights about this canonical signaling process.
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000423304200005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45485]
专题	中国科学院化学研究所
通讯作者	Fang, Xiaohong
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Rong,Li, Nan,Xu, Jiachao,et al. Quantitative single-molecule study of TGF-beta/Smad signaling[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2018,50(1):51-59.
APA	Zhao, Rong,Li, Nan,Xu, Jiachao,Li, Wenhui,&Fang, Xiaohong.(2018).Quantitative single-molecule study of TGF-beta/Smad signaling.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,50(1),51-59.
MLA	Zhao, Rong,et al."Quantitative single-molecule study of TGF-beta/Smad signaling".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 50.1(2018):51-59.