The effect of NDGA-modified etchant on the enzymatic degradation resistance and mechanical properties of collagen matrix

doi:10.1016/j.cclet.2017.08.036

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	The effect of NDGA-modified etchant on the enzymatic degradation resistance and mechanical properties of collagen matrix
	Gong, Shi-Qiang 1; Xue, Zhen-Jie 2; Liao, Shu-Teng 1; Wu, Ya-Bo 1; Liu, Yan 3
刊名	CHINESE CHEMICAL LETTERS
	2018
卷号	29 期号:1 页码:205-208
关键词	Ndga Crosslink Degradation Mechanical Properties Collagen
ISSN号	1001-8417
DOI	10.1016/j.cclet.2017.08.036
英文摘要	Enzymatic degradation of demineralized collagen matrix seriously impairs durable resin-dentin bonding. In this study, we evaluated the effect of nordihydroguaiaretic acid (NDGA)-modified etchant on the resistance to enzymatic degradation and mechanical properties of demineralized collagen matrix. Dentin beams were randomly demineralized by following solutions: 1) 10% phosphoric acid (PhA) solution, 2) 10% dimethyl sulfoxide (DMSO)-PhA solution, 3) NDGA-modified etchant, and 4) proanthocyanidins (PA)-modified etchant. The demineralized dentin collagen was then digested by type I collagenase solution. The collagenase degradation resistance was evaluated by measuring loss of dry mass, hydroxyproline release, and elastic modulus change. The degradation rate and hydroxyproline release of dentin collagen treated with NDGA-modified etchant were significantly lower than those in the other groups (P < 0.001). The elastic modulus of dentin beams treated with NDGA-modified etchant did not increase significantly. However, after 48 h of collagenase degradation, the loss of elastic modulus of dentin beams treated with NDGA-modified etchant was significantly lower than that of the control group (P < 0.001). The NDGA-modified etchant could improve the resistance to enzymatic degradation of type I collagenase degradation, and the stability of the mechanical properties of dentin collagen. This proof-of-concept study validates the etch-and-crosslink technique that improves durability of dentin bonding through simultaneous dentin etching and collagen crosslinking. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000423005300045
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45443]
专题	中国科学院化学研究所
通讯作者	Liu, Yan
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Ctr Stomatol, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China 3.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont,Beijing Key Lab Digital Stomatol, Lab Biomimet Nanomat,Natl Engn Lab Digital & Mat, Beijing 100081, Peoples R China
推荐引用方式 GB/T 7714	Gong, Shi-Qiang,Xue, Zhen-Jie,Liao, Shu-Teng,et al. The effect of NDGA-modified etchant on the enzymatic degradation resistance and mechanical properties of collagen matrix[J]. CHINESE CHEMICAL LETTERS,2018,29(1):205-208.
APA	Gong, Shi-Qiang,Xue, Zhen-Jie,Liao, Shu-Teng,Wu, Ya-Bo,&Liu, Yan.(2018).The effect of NDGA-modified etchant on the enzymatic degradation resistance and mechanical properties of collagen matrix.CHINESE CHEMICAL LETTERS,29(1),205-208.
MLA	Gong, Shi-Qiang,et al."The effect of NDGA-modified etchant on the enzymatic degradation resistance and mechanical properties of collagen matrix".CHINESE CHEMICAL LETTERS 29.1(2018):205-208.