Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids

doi:10.1002/smll.201702175

CORC > 化学研究所 > 中国科学院化学研究所

	Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids
	Wang, Juan 1,2; Yuan, Chengqian 1,2; Han, Yuchun 3; Wang, Yilin 3; Liu, Xiaomin 2,4; Zhang, Suojiang 2,4; Yan, Xuehai 1,2
刊名	SMALL
	2017-11-27
卷号	13 期号:44
关键词	Dipeptide Ionic Liquid Kinetics And Thermodynamics Self-assembly Trace Water
ISSN号	1613-6810
DOI	10.1002/smll.201702175
英文摘要	The interaction between water and biomolecules including peptides is of critical importance for forming high-level architectures and triggering life's functions. However, the bulk aqueous environment has limitations in detecting the kinetics and mechanisms of peptide self-assembly, especially relating to interactions of trace water. With ionic liquids (ILs) as a nonconventional medium, herein, it is discovered that trace amounts of water play a decisive role in triggering self-assembly of a biologically derived dipeptide. ILs provide a suitable nonaqueous environment, enabling us to mediate water content and follow the dynamic evolution of peptide self-assembly. The trace water is found to be involved in the assembly process of dipeptide, especially leading to the formation of stable noncovalent dipeptide oligomers in the early stage of nucleation, as evident by both experimental studies and theoretical simulations. The thermodynamics of the growth process is mainly governed by a synergistic effect of hydrophobic interaction and hydrogen bonds. Each step of assembly presents a different trend in thermodynamic energy. The dynamic evolution of assembly process can be efficiently mediated by changing trace water content. The decisive role of trace water in triggering and mediating self-assembly of biomolecules provides a new perspective in understanding supramolecular chemistry and molecular self-organization in biology.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000416040600008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45029]
专题	中国科学院化学研究所
通讯作者	Liu, Xiaomin; Yan, Xuehai
作者单位	1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Key Lab Colloid & Interface Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Juan,Yuan, Chengqian,Han, Yuchun,et al. Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids[J]. SMALL,2017,13(44).
APA	Wang, Juan.,Yuan, Chengqian.,Han, Yuchun.,Wang, Yilin.,Liu, Xiaomin.,...&Yan, Xuehai.(2017).Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids.SMALL,13(44).
MLA	Wang, Juan,et al."Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids".SMALL 13.44(2017).