Nanoprodrug of retinoic acid-modified paclitaxel

doi:10.1039/c7ob02553j

CORC > 化学研究所 > 中国科学院化学研究所

	Nanoprodrug of retinoic acid-modified paclitaxel
	Zhou, Zijun 1; Yan, Jingzhe 1; Sun, Tingting 2,3; Wang, Xin 4; Xie, Zhigang 2
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2017-12-07
卷号	15 期号:45 页码:9611-9615
ISSN号	1477-0520
DOI	10.1039/c7ob02553j
英文摘要	All-trans-retinoic acid (RA) is a non-toxic physiological metabolite of vitamin A. A paclitaxel (PTX) prodrug (RA-PTX) with high PTX content of 75% was synthesized via an easy condensation reaction. RA-PTX nanoparticles (RA-PTX NPs) were prepared through a nanoprecipitation method which increased the water solubility of PTX. RA-PTX NPs were spherical in shape and exhibited favorable structural stability in both water and the physiological environment. RA-PTX NPs possessed effective cellular uptake as revealed by confocal laser scanning microscopy and exerted potent cytotoxicity. These results highlight the potential of nanomedicines from PTX prodrugs for increasing the drug loading and water solubility of PTX.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000415990300012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45003]
专题	中国科学院化学研究所
通讯作者	Sun, Tingting
作者单位	1.Jilin Canc Hosp, 1018 Huguang St, Changchun 130012, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jilin Univ, Hosp 1, Dept Thyroid Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Zijun,Yan, Jingzhe,Sun, Tingting,et al. Nanoprodrug of retinoic acid-modified paclitaxel[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(45):9611-9615.
APA	Zhou, Zijun,Yan, Jingzhe,Sun, Tingting,Wang, Xin,&Xie, Zhigang.(2017).Nanoprodrug of retinoic acid-modified paclitaxel.ORGANIC & BIOMOLECULAR CHEMISTRY,15(45),9611-9615.
MLA	Zhou, Zijun,et al."Nanoprodrug of retinoic acid-modified paclitaxel".ORGANIC & BIOMOLECULAR CHEMISTRY 15.45(2017):9611-9615.