Self-immolative nanoparticles triggered by hydrogen peroxide and pH

doi:10.1002/pola.27203

CORC > 化学研究所 > 中国科学院化学研究所

	Self-immolative nanoparticles triggered by hydrogen peroxide and pH
	Wang, Zhijian; Sun, Jianbo; Jia, Xinru
刊名	JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
	2014-07-15
卷号	52 期号:14 页码:1962-1969
关键词	Nanoparticles Oligomers Step-growth Polymerization Stimuli-sensitive Polymers
ISSN号	0887-624X
DOI	10.1002/pola.27203
英文摘要	The azomethine-based oligomers bearing boronate groups and imine moieties in the main chain were synthesized from a dialdehyde monomer and an aromatic (oligomer 4) diamine or an aliphatic diamine (oligomer 5). Based on the oligomers, the nanoparticles with hydrogen peroxide (H2O2) and pH dual-responsive properties were constructed and encapsulated nile red inside. The nanoparticles disassembled either by the trigger of H2O2 or by the attack of H+, thus leading to the release of loaded species. Compared to oligomer 4, oligomer 5 showed a faster degradation rate in the presence of H2O2, especially in a weak acidic environment. No significant cytotoxicity was observed as HeLa cells incubated in the nanoparticles with the concentration up to 200 g/mL evidenced by cytotoxicity assay in vitro. Such a system capable of dual response of H2O2 and H+ may have potential application as a carrier for drug delivery. (c) 2014 Wiley Periodicals, Inc.
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000337682100005
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43459]
专题	中国科学院化学研究所
通讯作者	Jia, Xinru
作者单位	Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Polymer Chem & Phys, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhijian,Sun, Jianbo,Jia, Xinru. Self-immolative nanoparticles triggered by hydrogen peroxide and pH[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2014,52(14):1962-1969.
APA	Wang, Zhijian,Sun, Jianbo,&Jia, Xinru.(2014).Self-immolative nanoparticles triggered by hydrogen peroxide and pH.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,52(14),1962-1969.
MLA	Wang, Zhijian,et al."Self-immolative nanoparticles triggered by hydrogen peroxide and pH".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 52.14(2014):1962-1969.