Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity

doi:10.1016/j.jcis.2018.03.108

CORC > 化学研究所 > 中国科学院化学研究所

	Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity
	Li, Yawei 1,4; Liu, Wensen 1; Sun, Chengbiao 1; Zheng, Min 2; Zhang, Jianxu 3; Liu, Bin 1; Wang, Yan 1; Xie, Zhigang 3; Xu, Na 1,4
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2018-08-01
卷号	523 页码:226-233
关键词	Rtb Carbon Dots Nanoparticle Macrophage Immunomodulatory Activity
ISSN号	0021-9797
DOI	10.1016/j.jcis.2018.03.108
英文摘要	Although Ricin toxin binding subunit B (RTB) can promote the activation of macrophages and modulate the cell-mediated immunity, its applications are severely limited due to the intrinsic properties of proteins, like poor stability and low efficacy of cellular uptake. In this work, the stable nanoparticles were prepared by supramolecular assembling of carbon dots (CDs) and RTB. The formed CDs-RTB possesses robust stability and can protect RTB against enzymatic hydrolysis More importantly, CDs-RTB can promote macrophages proliferation, improve the generation of NO, 1L-6 and TNF-a in RAW264.7 cells and increase the expression of mRNA, indicating the enhanced immunomodulatory activity of CDs-RTB. This work highlights the potential of using CDs as a simple and stable platform to assemble RTB and effectively promotes the application of RTB as the lmmunostimulant. (C) 2018 Elsevier Inc. All rights reserved.
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000431745500024
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43185]
专题	中国科学院化学研究所
通讯作者	Zheng, Min; Xu, Na
作者单位	1.Acad Mil Med Sci, Inst Mil Vet Med, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Jilin, Peoples R China 2.Changchun Univ Technol, Chem & Life Sci Sch, Adv Inst Mat Sci, 2055 Yanan St, Changchun 130012, Jilin, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 4.Jilin Med Univ, Changchun 132013, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Li, Yawei,Liu, Wensen,Sun, Chengbiao,et al. Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2018,523:226-233.
APA	Li, Yawei.,Liu, Wensen.,Sun, Chengbiao.,Zheng, Min.,Zhang, Jianxu.,...&Xu, Na.(2018).Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity.JOURNAL OF COLLOID AND INTERFACE SCIENCE,523,226-233.
MLA	Li, Yawei,et al."Hybrids of carbon dots with subunit B of ricin toxin for enhanced immunomodulatory activity".JOURNAL OF COLLOID AND INTERFACE SCIENCE 523(2018):226-233.