Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy

doi:10.1002/adhm.201701357

CORC > 化学研究所 > 中国科学院化学研究所

	Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy
	Cao, Hongqian 1,2; Yang, Yang 2; Qi, Yanfei 1; Li, Yue 2; Sun, Bingbing 3; Li, Ying 2; Cui, Wei 3; Li, Juan 1; Li, Junbai 3
刊名	ADVANCED HEALTHCARE MATERIALS
	2018-06-20
卷号	7 期号:12
关键词	Immobilized Enzymes Intraparticle Fret Photodynamic Therapies Two-photon Excitation Vaterite Nanoparticles
ISSN号	2192-2640
DOI	10.1002/adhm.201701357
英文摘要	Photodynamic therapy (PDT) still faces two main problems on cancer therapy. One is how to improve PDT efficiency against hypoxic environment of tumors. The other one is how to overcome the limit of short wavelength light to increase PDT treatment depth. In this work, an intraparticle fluorescence resonance energy transfer (FRET) platform is designed to address these problems together. The nanoparticles are doped with multicomponents, such as catalase, two-photon dyes, and traditional photosensitizers, with a simple "one-pot" and green method. On the one hand, catalase can catalyze intracellular H2O2 into O-2 and promote PDT efficiency. One the other hand, photosensitizers can be excited indirectly by two-photon lasers through an intraparticle FRET mechanism, which results in deeper tissue penetration for PDT. These properties are verified through the material induced cytotoxicity in light or in dark and in vivo blocking blood-vessel experiment.
语种	英语
出版者	WILEY
WOS记录号	WOS:000435764200003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42533]
专题	中国科学院化学研究所
通讯作者	Yang, Yang; Li, Juan; Li, Junbai
作者单位	1.Jilin Univ, Sch Publ Hlth, Changchun 130021, Jilin, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cao, Hongqian,Yang, Yang,Qi, Yanfei,et al. Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(12).
APA	Cao, Hongqian.,Yang, Yang.,Qi, Yanfei.,Li, Yue.,Sun, Bingbing.,...&Li, Junbai.(2018).Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy.ADVANCED HEALTHCARE MATERIALS,7(12).
MLA	Cao, Hongqian,et al."Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy".ADVANCED HEALTHCARE MATERIALS 7.12(2018).