MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers

doi:10.1002/marc.201800258

CORC > 化学研究所 > 中国科学院化学研究所

	MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers
	Jin, Manyu 1; Zhang, Yanqun 2; Gao, Ge 2; Xi, Qiaoyue 1; Yang, Yun 3; Yan, Luomei 4; Zhou, Hua 6; Zhao, Yongxia 6; Wu, Cunqi 6; Wang, Lidan 5
刊名	MACROMOLECULAR RAPID COMMUNICATIONS
	2018-08-01
卷号	39 期号:16
关键词	Conjugated Polyelectrolytes Contrast Agents Dendritic Polymers Magnetic Resonance Imaging
ISSN号	1022-1336
DOI	10.1002/marc.201800258
英文摘要	Three complexes of gadolinium-based on dentritic molecules are reported as magnetic resonance imaging (MRI) contrast agents. Their ligands feature four carboxylate groups, which contribute to good water solubility and a strong combination with metal ions. As a new attempt, coupling polymerization is carried out to make a combination of conjugated polyelectrolytes and dendrimers for MRI contrast agents. For comparison, mononuclear and binuclear complexes are also reported. The investigation suggests that the contrast agent with the newly designed macromolecular skeleton provides higher longitudinal relaxivity value (36.2 mm(-1)s(-1)) and more visible enhancement in in vivo and in vitro MR images than the small molecular ones. In addition, extremely low cytotoxicity and main clearance via hepatobiliary are confirmed, which reduces the deterioration of chronic kidney disease. All the results indicate that these three complexes are generally applicable as promising clinical contrast agents.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000442218900003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42329]
专题	中国科学院化学研究所
通讯作者	Lei, Yongqian; Yang, Wei; Xu, Jingwei
作者单位	1.Univ Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Chinese Acad Sci, Changchun 130022, Jilin, Peoples R China 2.Univ Sci & Technol China, Changchun Inst Appl Chem, Chinese Acad Sci, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 3.Univ Sci & Technol China, Changchun Inst Appl Chem, Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 4.Xinjiang Med Univ, Sch Pharmaceut Sci, Urumqi 830000, Peoples R China 5.Quanzhou Normal Univ, Coll Chem Engn & Mat, Quanzhou 362000, Peoples R China 6.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 7.Guangdong Inst Anal, Guangdong Prov Key Lab Emergency Test Dangerous C, Guangzhou 510070, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Jin, Manyu,Zhang, Yanqun,Gao, Ge,et al. MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2018,39(16).
APA	Jin, Manyu.,Zhang, Yanqun.,Gao, Ge.,Xi, Qiaoyue.,Yang, Yun.,...&Xu, Jingwei.(2018).MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers.MACROMOLECULAR RAPID COMMUNICATIONS,39(16).
MLA	Jin, Manyu,et al."MRI Contrast Agents Based on Conjugated Polyelectrolytes and Dendritic Polymers".MACROMOLECULAR RAPID COMMUNICATIONS 39.16(2018).