Multiple Targeted Drugs Carrying Biodegradable Membrane Barrier: Anti-Adhesion, Hemostasis, and Anti-Infection

doi:10.1021/bm301997e

CORC > 化学研究所 > 中国科学院化学研究所

	Multiple Targeted Drugs Carrying Biodegradable Membrane Barrier: Anti-Adhesion, Hemostasis, and Anti-Infection
	Wang, Heran 1,2; Li, Min 3; Hu, Jianming 3; Wang, Chenhong 1,2; Xu, Shanshan 1; Han, Charles C.1
刊名	BIOMACROMOLECULES
	2013-04-01
卷号	14 期号:4 页码:954-961
ISSN号	1525-7797
DOI	10.1021/bm301997e
英文摘要	A multiple targeted drug carrying bilayer layer membrane for preventing an; abdominal adhesion is prepared by electrospinning. Two bioactive drugs were I successfully incorporated into this bilayer membrane and can be independently released from nanofibrous scaffolds without losing structural integrity and functionality of the anti-adhesion membrane. Besides, the drug release profile could be easily: adjusted by optimizing the swelling behavior of the fibrous scaffold. The inner layer of the bilayered fibrous membranes loaded with carbazochrome sodium sulfonate (CA) showed an excellent vascular hemostatic efficacy and formed little clot during in vivo experiment. The outer layer loaded with tinidazole (TI) had outstanding antibacterial effect against the anaerobe. We believe this approach could serve as a model technique to guide the design of implants with drug delivery functions.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000317370500003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42127]
专题	中国科学院化学研究所
通讯作者	Xu, Shanshan
作者单位	1.Chinese Acad Sci, Inst Chem,Beijing Natl Lab Mol Sci, Joint Lab Polymer Sci & Mat, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Soochow Univ, Affiliated Hosp 1, Suzhou 215000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Heran,Li, Min,Hu, Jianming,et al. Multiple Targeted Drugs Carrying Biodegradable Membrane Barrier: Anti-Adhesion, Hemostasis, and Anti-Infection[J]. BIOMACROMOLECULES,2013,14(4):954-961.
APA	Wang, Heran,Li, Min,Hu, Jianming,Wang, Chenhong,Xu, Shanshan,&Han, Charles C..(2013).Multiple Targeted Drugs Carrying Biodegradable Membrane Barrier: Anti-Adhesion, Hemostasis, and Anti-Infection.BIOMACROMOLECULES,14(4),954-961.
MLA	Wang, Heran,et al."Multiple Targeted Drugs Carrying Biodegradable Membrane Barrier: Anti-Adhesion, Hemostasis, and Anti-Infection".BIOMACROMOLECULES 14.4(2013):954-961.