Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine

doi:10.1021/acsnano.8b03476

CORC > 化学研究所 > 中国科学院化学研究所

	Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine
	He, Shasha 1,2; Le, Chan 5,6; Zhang, Qingfei 1,2; Ding, Jianxun 7; Liang, Xing-Jie 5,6; Chen, Xuesi 7; Xiao, Haihua 2,4; Chen, Xiaoyuan 1,3; Zhou, Dongfang 1; Huang, Yubin 1
刊名	ACS NANO
	2018-07-01
卷号	12 期号:7 页码:7272-7281
关键词	Precise Nanomedicine Platinum Amphiphile Photoactivatable Targeting Imaging
ISSN号	1936-0851
DOI	10.1021/acsnano.8b03476
英文摘要	Drug, targeting ligand, and imaging agent are the three essential components in a nanoparticle-based drug delivery system. However, tremendous batch-to-batch variation of composition and drug content typically accompany the current approaches of building these components together. Herein, we report the design of photoactivatable platinum(IV) (Pt(IV)) amphiphiles containing one or two hydrophilic lactose targeting ligands per hydrophobic Pt(IV) prodrug for an all-in one precise nanomedicine. Self-assembly of these Pt(IV) amphiphiles results in either micelle or vesicle formation with a fixed Pt/targeting moiety ratio and a constantly high content of Pt. The micelles and vesicles are capable of hepatoma cell targeting, fluorescence/Pt-based CT imaging and have shown effective anticancer efficacy under laser irradiation in vitro and in vivo. This photoactivatable, active self-targeting, and multimodal theranostic amphiphile strategy shows great potential in constructing precise nanomedicine.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000440505000094
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/41907]
专题	中国科学院化学研究所
通讯作者	Xiao, Haihua; Chen, Xiaoyuan; Zhou, Dongfang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA 4.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Lab Controllable Nanopharmaceut, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China
推荐引用方式 GB/T 7714	He, Shasha,Le, Chan,Zhang, Qingfei,et al. Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine[J]. ACS NANO,2018,12(7):7272-7281.
APA	He, Shasha.,Le, Chan.,Zhang, Qingfei.,Ding, Jianxun.,Liang, Xing-Jie.,...&Huang, Yubin.(2018).Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine.ACS NANO,12(7),7272-7281.
MLA	He, Shasha,et al."Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine".ACS NANO 12.7(2018):7272-7281.