Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects

doi:10.1007/s11705-018-1729-4

	Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects
	Qi, F; Wu, J; Li, H; Ma, GH; Qi, Feng; Wu, Jie; Li, Hao; Ma, Guanghui
刊名	FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
	2019
卷号	13 期号:1 页码:14
关键词	PLGA DEXAMETHASONE INTRAVITREAL IMPLANT microspheres SUPERCRITICAL EMULSION EXTRACTION drug delivery system MEMBRANE EMULSIFICATION TECHNIQUE stability SUSTAINED-RELEASE manufacturing IN-VITRO PICKERING EMULSIONS FACIAL LIPOATROPHY PLA MICROCAPSULES SIZE DISTRIBUTION GROWTH-FACTOR
ISSN号	2095-0179
DOI	10.1007/s11705-018-1729-4
文献子类	Review
英文摘要	Poly(D,L-lactic-co-glycolic acid) (PLGA)/poly (lactic acid) (PLA) microspheres/nanoparticles are one of the most successful drug delivery systems (DDS) in lab and clinic. Because of good biocompatibility and biodegradability, they can be used in various areas, such as long-term release system, vaccine adjuvant, tissue engineering, etc. There have been 15 products available on the US market, but the system still has many problems during development and manufacturing, such as wide size distribution, drug stability issues, and so on. Recently, many new and modified methods have been developed to overcome the above problems. Some of the methods are easy to scale up, and have been available on the market to achieve pilot scale or even industrial production scale. Furthermore, the relevant FDA guidance on the DDS is still incomplete, especially for abbreviated new drug application. In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the development of the system in pharmaceutical industry.
WOS记录号	WOS:000460491000002
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28324]
专题	中国科学院过程工程研究所
推荐引用方式 GB/T 7714	Qi, F,Wu, J,Li, H,et al. Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2019,13(1):14, 27.
APA	Qi, F.,Wu, J.,Li, H.,Ma, GH.,Qi, Feng.,...&Ma, Guanghui.(2019).Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,13(1),14.
MLA	Qi, F,et al."Recent research and development of PLGA/PLA microspheres/nanoparticles: A review in scientific and industrial aspects".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 13.1(2019):14.