Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy

doi:10.1039/c8mh01286e

	Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy
	Shen, Qi 1,2; Yang, Jun 1; Liu, Ruiyuan 1; Liu, Linying 1; Zhang, Jinchao 2; Shen, Shigang 2; Zhang, Xin 1
刊名	MATERIALS HORIZONS
	2019-04-01
卷号	6 期号:4 页码:810-816
ISSN号	2051-6347
DOI	10.1039/c8mh01286e
英文摘要	A hybrid clusterbomb' as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to bomb' in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity.
资助项目	National High Technology Research and Development Program[2016YFA-0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[51573188] ; National Natural Science Foundation of China[31522023] ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences[XDA09030301-3] ; Beijing Municipal Science & Technology Commission[Z161100002616015] ; Beijing Natural Science Foundation[L172046]
WOS关键词	DELIVERY ; VACCINE ; SYSTEM ; NANOVACCINE ; MICELLES ; BARRIER ; CELLS
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000466314400013
资助机构	National High Technology Research and Development Program ; National Natural Science Foundation of China ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28261]
专题	中国科学院过程工程研究所
通讯作者	Shen, Shigang; Zhang, Xin
作者单位	1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
推荐引用方式 GB/T 7714	Shen, Qi,Yang, Jun,Liu, Ruiyuan,et al. Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy[J]. MATERIALS HORIZONS,2019,6(4):810-816.
APA	Shen, Qi.,Yang, Jun.,Liu, Ruiyuan.,Liu, Linying.,Zhang, Jinchao.,...&Zhang, Xin.(2019).Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy.MATERIALS HORIZONS,6(4),810-816.
MLA	Shen, Qi,et al."Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy".MATERIALS HORIZONS 6.4(2019):810-816.