Oxygen content determines the bio-reactivity and toxicity profiles of carbon black particles

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Oxygen content determines the bio-reactivity and toxicity profiles of carbon black particles
	Zuo, Yi Y.; Wu, Yakun; Guo, Yifan; Song, Haoyang; Liu, Wei; Yang, Yi; Liu, Yajun; Sang, Nan; Liu, Sijin
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2018-04-15
卷号	150 页码:207-214
关键词	PM2.5 Carbon black Cytotoxicity Inflammatory responses Lung Macrophage
ISSN号	0147-6513
文献子类	Article
英文摘要	In spite of the considerable efforts invested to understand the environmental health and safety (EHS) impacts of ultrafine particles, such as the representative PM2.5, there are still significant knowledge gaps to be filled. No conclusive understandings have been obtained about the physicochemical determinants in accounting for differential adverse outcomes. Here we compared the cytotoxicity of four carbon black (CB) particles with similar physicochemical properties except for their oxygen contents (C824455 < C1864 < Printex U < SB4A). We found that these four CB particles manifested in vitro and in vivo cytotoxicity reversely related to their oxygen contents, namely a hierarchy of cytotoxicity: C824455 > C1864 > Printex U > SB4A. Among these CB particles, the most significant lung injury (e.g. collapses and inflammation) and macrophagic activation were found for C824455 and C1864, in particular for C824455. All these differences in toxicity profiles, including in vitro and in vivo cytotoxicity, pro-inflammatory effects and direct damages to the lung epithelia, should be (at least partially) ascribed to the oxygen content in these CB particles that in turn determined their transformation, i.e. the different aggregation states. Nonetheless, PM2.5 likewise caused severe in vivo and in vitro toxicities to the lung cells and macrophages. This study thus offers more insights into the structure-activity relationship (SAR) and opens a new avenue to elucidate the physicochemical determinants in evoking lung injuries by ultrafine airborne particles.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41008]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zuo, Yi Y.,Wu, Yakun,Guo, Yifan,et al. Oxygen content determines the bio-reactivity and toxicity profiles of carbon black particles[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2018,150:207-214.
APA	Zuo, Yi Y..,Wu, Yakun.,Guo, Yifan.,Song, Haoyang.,Liu, Wei.,...&Liu, Sijin.(2018).Oxygen content determines the bio-reactivity and toxicity profiles of carbon black particles.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,150,207-214.
MLA	Zuo, Yi Y.,et al."Oxygen content determines the bio-reactivity and toxicity profiles of carbon black particles".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 150(2018):207-214.