Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension

doi:10.1148/radiol.2018180425

	Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension
	Qi, Xiaolong 1,2; An, Weimin 3; Liu, Fuquan 6; Qi, Ruizhao 4; Wang, Lei 6; Liu, Yanna 2; Liu, Chuan 2; Xiang, Yi 2; Hui, Jialiang 2; Liu, Zhao 2
刊名	RADIOLOGY
	2019-02-01
卷号	290 期号:2 页码:370-377
ISSN号	0033-8419
DOI	10.1148/radiol.2018180425
通讯作者	Qi, Xiaolong(qixiaelong@vip.163.com)
英文摘要	Purpose: To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods: In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21-75 years]; 68 men with a mean age of 44 years [range, 21-73 years] and 34 women with a mean age of 52 years [range, 24-75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017. All participants with cirrhosis of various causes underwent transjugular HVPG measurement, Doppler US, and CT angiography. Virtual HVPG was developed with a three-dimensional reconstructed model and computational fluid dynamics. Results: In the training cohort (n = 29), the area under the receiver operating characteristic curve (AUC) of virtual HVPG in the prediction of clinically significant portal hypertension (CSPH) was 0.83 (95% confidence interval [CI]: 0.58, 1.00). The diagnostic performance was prospectively confirmed in the validation cohort (n = 73), with an AUC of 0.89 (95% CI: 0.81, 0.96). Inter-and intraobserver agreement was 0.88 and 0.96, respectively, suggesting the good reproducibility of virtual HVPG measurements. There was good correlation between virtual HVPG and invasive HVPG (R = 0.61, P<.001), with a satisfactory performance to rule out (7.3 mm Hg) and rule in (13.0 mm Hg) CSPH. Conclusion: The accuracy of a computational model of virtual hepatic venous pressure gradient (HVPG) shows significant correlation with invasive HVPG. The virtual HVPG also showed a good performance in the noninvasive diagnosis of clinically significant portal hypertension in cirrhosis. (c) RSNA, 2018
资助项目	Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation[pdjha0096] ; Nanfang Hospital Southern Medical University[2017Z012] ; Beijing Municipal Administration of Hospitals Ascent Plan[DFL20151602] ; Application Research on Clinical Characteristics of the Capital[z161100000516197] ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project[201704020015] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding[ZYLX201610] ; Program for Development and Cultivation of Science and Technology of Southern Medical University[KJ20161125] ; National Natural Science Foundation of China[81600510] ; National Natural Science Foundation of China[81672725] ; Guangdong Science Fund for Distinguished Young Scholars[2018B030306019] ; Capital's Funds for Health Improvement and Research[2018-1-2081]
WOS关键词	LIVER STIFFNESS MEASUREMENT ; MANAGEMENT ; FIBROSIS ; VARICES
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	RADIOLOGICAL SOC NORTH AMERICA
WOS记录号	WOS:000456444200018
资助机构	Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation ; Nanfang Hospital Southern Medical University ; Beijing Municipal Administration of Hospitals Ascent Plan ; Application Research on Clinical Characteristics of the Capital ; Guangzhou Industry-Academia-Research Collaborative Innovation Major Project ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding ; Program for Development and Cultivation of Science and Technology of Southern Medical University ; National Natural Science Foundation of China ; Guangdong Science Fund for Distinguished Young Scholars ; Capital's Funds for Health Improvement and Research
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25329]
专题	中国科学院自动化研究所
通讯作者	Qi, Xiaolong
作者单位	1.Lanzhou Univ, CHESS Frontier Ctr, Chinese Portal Hypertens Diag & Monitoring Study, Lanzhou, Gansu, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Inst Hepatol, Hepat Hemodynam Lab, Guangzhou, Guangdong, Peoples R China 3.302 Hosp PLA, Dept Radiol, Beijing, Peoples R China 4.302 Hosp PLA, Dept Gen Surg, Beijing, Peoples R China 5.302 Hosp PLA, Ctr Therapeut Res Hepatocarcinoma, Beijing, Peoples R China 6.Capital Med Univ, Dept Intervent Therapy, Beijing Shijitan Hosp, Beijing, Peoples R China 7.Gen Hosp Shenyang Mil Area, Dept Gastroenterol, Shenyang, Liaoning, Peoples R China 8.Sun Yat Sen Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 9.Sun Yat Sen Univ, Organ Transplant Ctr, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China 10.Capital Med Univ, Beijing Youan Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Qi, Xiaolong,An, Weimin,Liu, Fuquan,et al. Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension[J]. RADIOLOGY,2019,290(2):370-377.
APA	Qi, Xiaolong.,An, Weimin.,Liu, Fuquan.,Qi, Ruizhao.,Wang, Lei.,...&Li, Zhiwei.(2019).Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension.RADIOLOGY,290(2),370-377.
MLA	Qi, Xiaolong,et al."Virtual Hepatic Venous Pressure Gradient with CT Angiography (CHESS 1601): A Prospective Multicenter Study for the Noninvasive Diagnosis of Portal Hypertension".RADIOLOGY 290.2(2019):370-377.