Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging

doi:10.1016/j.ejrad.2019.01.008

	Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging
	Xi, Yi-bin 1; Kang, Xiao-wei 1; Wang, Ning 1; Liu, Ting-ting 1; Zhu, Yuan-qiang 1; Cheng, Guang 2; Wang, Kai 2; Li, Chen 1; Guo, Fan 1,3; Yin, Hong 1
刊名	EUROPEAN JOURNAL OF RADIOLOGY
	2019-03-01
卷号	112 页码:59-64
关键词	Primary central nervous system lymphoma High-grade glioma Metastasis Arterial spin labeling Dynamic contrast-enhanced perfusion
ISSN号	0720-048X
DOI	10.1016/j.ejrad.2019.01.008
通讯作者	Guo, Fan(guofan@fmmu.edu.cn) ; Yin, Hong(yinhong@fmmu.edu.cn)
英文摘要	Background and purpose: Conventional magnetic resonance imaging (MRI) is sometimes difficult to distinguish primary central nervous system lymphoma (PCNSL) from other malignant brain tumors effectively. The study aimed to evaluate the diagnostic performance of arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE)-derived permeability parameters to differentiate PCNSL from high-grade glioma (HGG) and brain metastasis. Materials and methods: Eight patients with PCNSL, twenty one patients with HGG and six brain metastasis underwent preoperative 3.0-T MR imaging including conventional, ASL and DCE. Quantitative parameters including relative cerebral blood flow (rCBF), extravascular extracellular volume fraction (V-e) and the volume transfer constant (K-trans) among PCNSL, HGG and metastasis were compared with a one-way analysis of variance. In addition, the area under the receiver-operating characteristic (ROC) curve (AUC) was constructed to evaluate the differentiation diagnostic performance of each parameter and the combination. Results: The PCNSL demonstrated significantly lower rCBF, higher K-trans and V-e compared with HGG and metastasis. For the ROC analyses, both K-trans and rCBF had good diagnostic performance for discriminating PCNSL from HGG and metastasis, with the AUC of 0.880 and 0.889. With the combination of rCBF and K-trans the diagnostic ability for PCNSL was improved with AUC of 0.986. Conclusion: rCBF and K-trans are useful parameters for differentiating PCNSL from HGG and brain metastasis. The combination of rCBF and K-trans further helps to improve the diagnostic performance of PCNSL.
资助项目	National Natural Science Foundation of China[81400952] ; National Natural Science Foundation of China[81372457]
WOS关键词	PRIMARY CNS LYMPHOMA ; GLIOBLASTOMA-MULTIFORME ; PERFUSION MRI ; DIFFUSION ; PERMEABILITY ; VOLUME ; TUMORS
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000458752500009
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25030]
专题	中国科学院自动化研究所
通讯作者	Guo, Fan; Yin, Hong
作者单位	1.Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Shaanxi, Peoples R China 2.Fourth Mil Med Univ, Xijing Hosp, Xijing Inst Clin Neurosci, Dept Neurosurg, Xian 710032, Shaanxi, Peoples R China 3.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xi, Yi-bin,Kang, Xiao-wei,Wang, Ning,et al. Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging[J]. EUROPEAN JOURNAL OF RADIOLOGY,2019,112:59-64.
APA	Xi, Yi-bin.,Kang, Xiao-wei.,Wang, Ning.,Liu, Ting-ting.,Zhu, Yuan-qiang.,...&Yin, Hong.(2019).Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging.EUROPEAN JOURNAL OF RADIOLOGY,112,59-64.
MLA	Xi, Yi-bin,et al."Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging".EUROPEAN JOURNAL OF RADIOLOGY 112(2019):59-64.