Molecular mechanism of the tree shrew’s insensitivity to spiciness | |
Ren Lai4; Yalan Han4,5; Guo-Dong Wang6,7; Ting-Ting Yin5,6; Shilong Yang4; Fan Yang2; Yaping Zhang5; Jie Zheng3; Cheng Xu4,5; Lizhen Xu2 | |
刊名 | PLOS Biology
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2018 | |
卷号 | 16期号:7页码:e2004921 |
DOI | 10.1371/journal.pbio.2004921 |
英文摘要 | Spicy foods elicit a pungent or hot and painful sensation that repels almost all mammals.Here, we observe that the tree shrew (Tupaia belangeri chinensis), which possesses aclose relationship with primates and can directly and actively consume spicy plants. Ourgenomic and functional analyses reveal that a single point mutation in the tree shrew’s tran-sient receptor potential vanilloid type-1 (TRPV1) ion channel (tsV1) lowers its sensitivity tocapsaicinoids, which enables the unique feeding behavior of tree shrews with regards topungent plants. We show that strong selection for this residue in tsV1 might be driven byPiper boehmeriaefolium, a spicy plant that geographically overlaps with the tree shrew andproduces Cap2, a capsaicin analog, in abundance. We propose that the mutation in tsV1 isa part of evolutionary adaptation that enables the tree shrew to tolerate pungency, thus wid-ening the range of its diet for better survival. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12404] ![]() |
专题 | 昆明动物研究所_动物毒素室 |
通讯作者 | Fan Yang; Yaping Zhang; Jie Zheng |
作者单位 | 1.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Department of Biophysicsand Kidney Disease Center, First Affiliated Hospital, Institute of Neuroscience, National Health Commission and Chinese Academy of Medical Sciences Key Laboratoryof Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China 3.Department of Physiology and Membrane Biology, University of California, Davis, Davis, California, United States of America 4.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratoryof bioactive peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan,China, 5.University of Chinese Academy of Sciences,Beijing, China, 6.State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratoryof Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 7.Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, Yunnan,China |
推荐引用方式 GB/T 7714 | Ren Lai,Yalan Han,Guo-Dong Wang,et al. Molecular mechanism of the tree shrew’s insensitivity to spiciness[J]. PLOS Biology,2018,16(7):e2004921. |
APA | Ren Lai.,Yalan Han.,Guo-Dong Wang.,Ting-Ting Yin.,Shilong Yang.,...&Rose Ombati.(2018).Molecular mechanism of the tree shrew’s insensitivity to spiciness.PLOS Biology,16(7),e2004921. |
MLA | Ren Lai,et al."Molecular mechanism of the tree shrew’s insensitivity to spiciness".PLOS Biology 16.7(2018):e2004921. |
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