LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes | |
Yun Stone Shi2,3; Nengyin Sheng1,2,5; Michael A. Bemben2; Javier Díaz-Alonso2; Wucheng Tao2; Roger A. Nicoll2,4 | |
刊名 | PNAS |
2018 | |
卷号 | 115期号:15页码:3948–3953 |
关键词 | Long-term Potentiation Glutamate Receptor Auxiliary Protein Pdz-binding Domain |
DOI | 10.1073/pnas.1800719115 |
英文摘要 | Long-term potentiation (LTP) is a persistent strengthening ofsynaptic transmission in the brain and is arguably the mostcompelling cellular and molecular model for learning and memory.Previous work found that both AMPA receptors and exogenouslyexpressed kainate receptors are equally capable of expressing LTP,despite their limited homology and their association with distinctauxiliary subunits, indicating that LTP is far more promiscuousthan previously thought. What might these two subtypes ofglutamate receptor have in common? Using a single-cell molecularreplacement strategy, we demonstrate that the AMPA receptorauxiliary subunit TARP γ-8, via its PDZ-binding motif, is indispens-able for both basal synaptic transmission and LTP. Remarkably,kainate receptors and their auxiliary subunits Neto proteins sharethe same requirement of PDZ-binding domains for synaptic traf-ficking and LTP. Together, these results suggest that a minimalpostsynaptic requirement for LTP is the PDZ binding of glutamatereceptors/auxiliary subunits to PSD scaffolding proteins. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12329] |
专题 | 遗传资源与进化国家重点实验室_神经突触机制与功能研究组(盛能印) |
通讯作者 | Nengyin Sheng; Roger A. Nicoll |
作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China 2.Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 3.Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 4.Department of Physiology, University of California, San Francisco, CA 94143 5.Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223 Yunnan, China |
推荐引用方式 GB/T 7714 | Yun Stone Shi,Nengyin Sheng,Michael A. Bemben,et al. LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes[J]. PNAS,2018,115(15):3948–3953. |
APA | Yun Stone Shi,Nengyin Sheng,Michael A. Bemben,Javier Díaz-Alonso,Wucheng Tao,&Roger A. Nicoll.(2018).LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes.PNAS,115(15),3948–3953. |
MLA | Yun Stone Shi,et al."LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes".PNAS 115.15(2018):3948–3953. |
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