Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans

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	Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans
	Miao HL 2; Zhang JJ 2,5; Hao JJ 1; Zhang YR 3; Liang B2,5; Zou XJ4; Li MY 2; Wang YL 5
刊名	Journal of Lipid Research
	2017
卷号	期号:页码:Epub ahead of print
关键词	Enzymology/enzyme Regulation Fatty Acid/biosynthesis Lipid Droplets Nuclear Receptors/srebp Triglycerides Stearoyl-coa Desaturase
其他题名	liangb@mail.kiz.ac.cn and xiaojuzou@163.com.
英文摘要	Maintenance of lipid homeostasis is crucial for cells in response to lipid requirements or surplus. The SREBPs transcription factors play essential roles in regulating lipid metabolism and are associated with many metabolic diseases. However, SREBP regulation of lipid metabolism is still less understood. Here, we show that reduction of SBP-1, the only homologue of SREBPs in C. elegans, surprisingly leads to high level of zinc. On the contrary, zinc reduction by mutation of sur-7, encoding a member of the cation diffusion facilitator (CDF) family, restores the fat accumulation and fatty acid profile of sbp-1(ep79) mutant. Zinc reduction results in iron overload, whichthereby directly activates the conversion activity of stearoyl-CoA desaturase (SCD), a main target of SREBP, to promote lipid biosynthesis and accumulation. However, zinc reduction reversely represses SBP-1 nuclear translocation, further down-regulates the transcription expression of SCD as for compensation. Collectively, we reveal zinc-mediated regulation of the SREBP-SCD axis in lipid metabolism distinct from the negative regulation of SREBP-1 or SREBP-2 by phosphatidylcholine (PC) or cholesterol, respectively, thereby providing novel insights into the regulation of lipid homeostasis.
语种	英语
资助机构	This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030600), National Natural Science Foundation of China (31671230, 31600963, 31171134, U1202223, 31401014, 31460268), Natural Science Foundation of Yunnan Province (P0120160119, 2013FA042), Yunnan Provincial Science and Technology Department (2014HB022), Yunnan Oversea High-level Talents Program (2015HA040), and China Postdoctoral Science Foundation (2017M613018). The authors declare that they have no competing interests. ; This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB13030600), National Natural Science Foundation of China (31671230, 31600963, 31171134, U1202223, 31401014, 31460268), Natural Science Foundation of Yunnan Province (P0120160119, 2013FA042), Yunnan Provincial Science and Technology Department (2014HB022), Yunnan Oversea High-level Talents Program (2015HA040), and China Postdoctoral Science Foundation (2017M613018). The authors declare that they have no competing interests.
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11893]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_进化与功能基因组学昆明动物研究所_脂类代谢与疾病
作者单位	1.State Key Laboratory of Genetic Resources and Evolutionary & Functional Genomics, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China 2.Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China 3.College of Fisheries, Henan Normal University, Xinxiang, Henan, 453007, China 4.Department of Life Science and Biotechnology, Key Laboratory of Special Biological Resource Development and Utilization of University in Yunnan Province, Kunming University, Kunming, 650214, China 5.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
推荐引用方式 GB/T 7714	Miao HL,Zhang JJ,Hao JJ,et al. Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans[J]. Journal of Lipid Research,2017,():Epub ahead of print.
APA	Miao HL.,Zhang JJ.,Hao JJ.,Zhang YR.,Liang B.,...&Wang YL.(2017).Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans.Journal of Lipid Research,(*),Epub ahead of print.
MLA	Miao HL,et al."Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans".Journal of Lipid Research .(2017):Epub ahead of print.