Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室

	Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?
	yaoyg@mail.kiz.ac.cn ; Yao YG*1,2
刊名	Zoological Research
	2017
卷号	38 期号:3 页码:118-126
关键词	Chinese Tree Shrew Genome Biology Animal Model Gene Editing Innate Immunity
英文摘要	The Chinese tree shrew (Tupaia belangeri chinensis), a squirrel-like and rat-sized mammal, has a wide distribution in Southeast Asia, South and Southwest China and has many unique characteristics that make it suitable for use as an experimental animal. There have been many studies using the tree shrew (Tupaia belangeri) aimed at increasing our understanding of fundamental biological mechanisms and for the modeling of human diseases and therapeutic responses. The recent release of a publicly available annotated genome sequence of the Chinese tree shrew and its genome database (www.treeshrewdb.org) has offered a solid base from which it is possible to elucidate the basic biological properties and create animal models using this species. The extensive characterization of key factors and signaling pathways in the immune and nervous systems has shown that tree shrews possess both conserved and unique features relative to primates. Hitherto, the tree shrew has been successfully used to create animal models for myopia, depression, breast cancer, alcohol-induced or non-alcoholic fatty liver diseases, herpes simplex virus type 1 (HSV-1) and hepatitis C virus (HCV) infections, to name a few. The recent successful genetic manipulation of the tree shrew has opened a new avenue for the wider usage of this animal in biomedical research. In this opinion paper, I attempt to summarize the recent research advances that have used the Chinese tree shrew, with a focus on the new knowledge obtained by using the biological properties identified using the tree shrew genome, a proposal for the genome-based approach for creating animal models, and the genetic manipulation of the tree shrew. With more studies using this species and the application of cutting-edge gene editing techniques, the tree shrew will continue to be under the spot light as a viable animal model for investigating the basis of many different human diseases.
语种	英语
资助机构	This study was supported by the grant of the National Natural Science Foundation of China (NSFC U1402224) and the Chinese Academy of Sciences (CAS zsys-02) ; This study was supported by the grant of the National Natural Science Foundation of China (NSFC U1402224) and the Chinese Academy of Sciences (CAS zsys-02) ; This study was supported by the grant of the National Natural Science Foundation of China (NSFC U1402224) and the Chinese Academy of Sciences (CAS zsys-02) ; This study was supported by the grant of the National Natural Science Foundation of China (NSFC U1402224) and the Chinese Academy of Sciences (CAS zsys-02)
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11733]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_重大疾病机理的遗传学昆明动物研究所_中国科学院昆明灵长类研究中心
通讯作者	yaoyg@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China 2.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China
推荐引用方式 GB/T 7714	yaoyg@mail.kiz.ac.cn,Yao YG*. Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?[J]. Zoological Research,2017,38(3):118-126.
APA	yaoyg@mail.kiz.ac.cn,&Yao YG*.(2017).Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?.Zoological Research,38(3),118-126.
MLA	yaoyg@mail.kiz.ac.cn,et al."Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?".Zoological Research 38.3(2017):118-126.