Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway

doi:10.1038/s41419-019-1560-y

	Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway
	Xu, Chunyan 1; Han, Yang 1; Zhang, Lin 1; Yu, Xiao 2; Wang, Shidan 1; Yin, Heng 3; Wang, Shujing 1
刊名	CELL DEATH & DISEASE
	2019-05-10
卷号	10 页码:14
ISSN号	2041-4889
DOI	10.1038/s41419-019-1560-y
通讯作者	Yin, Heng(yinheng@dicp.ac.cn) ; Wang, Shujing(wangshujing@dlmedu.edu.cn)
英文摘要	Chitosan oligosaccharides have been reported to inhibit various tumors. However, the water-soluble marine plant oligosaccharide alginate oligosaccharide (AOS) has only rarely been reported to have anti-cancer effects. Moreover, the inhibitory effect of AOS on prostate cancer and the underlying molecular mechanism remain unknown. This study shows that AOS inhibited cell growth, which was consistent with the attenuation of alpha 2,6-sialylation modification. Furthermore, AOS inhibited ST6Gal-1 promoter activity and thus affected transcriptional processes. In addition, AOS could activate the Hippo/YAP pathway and block the recruitment of both the coactivator YAP and c-Jun. Furthermore, YAP interacted with the transcription factor c-Jun and regulated the transcriptional activity of the downstream target ST6Gal-1 gene. Consistent with in vitro data, AOS suppressed the tumorigenicity of prostate cancer cells via the Hippo/YAP pathway in vivo. In summary, these data indicate that AOS slows the proliferation of prostate cancer and provides a basis for the healthy function of kelp in traditional cognition.
资助项目	National Natural Science Foundation of China[31470799] ; Natural Science Foundation of Liaoning Province[20170540288] ; Special Fund of Dalian city for Distinguished Young Scholars[2017RJ07] ; National Key R&D Program of China[2017YF0200900] ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences
WOS关键词	BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE ; C-JUN ; ENDOPLASMIC-RETICULUM ; COLON-CANCER ; SIALYLATION ; EXPRESSION ; INVASION ; ADHESION ; GLYCANS ; DEATH
WOS研究方向	Cell Biology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000468671400001
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Special Fund of Dalian city for Distinguished Young Scholars ; Special Fund of Dalian city for Distinguished Young Scholars ; National Key R&D Program of China ; National Key R&D Program of China ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences ; Liaoning Provincial Program for Top Discipline of Basic Medical Sciences
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171933]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yin, Heng; Wang, Shujing
作者单位	1.Dalian Med Univ, Coll Basic Med Sci, Inst Glycobiol, Dept Biochem & Mol Biol, Dalian, Liaoning, Peoples R China 2.Dalian Med Univ, Coll Basic Med Sci, Dept Pathol, Dalian, Liaoning, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Xu, Chunyan,Han, Yang,Zhang, Lin,et al. Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway[J]. CELL DEATH & DISEASE,2019,10:14.
APA	Xu, Chunyan.,Han, Yang.,Zhang, Lin.,Yu, Xiao.,Wang, Shidan.,...&Wang, Shujing.(2019).Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway.CELL DEATH & DISEASE,10,14.
MLA	Xu, Chunyan,et al."Alginate oligosaccharide attenuates alpha 2,6-sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway".CELL DEATH & DISEASE 10(2019):14.