The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles

doi:10.7536/PC150513

	The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles
	Ding Peng 2; Chen Xian 2; Li Xiuling 1; Qing Guangyan 2; Sun Taolei 2,3; Liang Xinmiao 1
刊名	PROGRESS IN CHEMISTRY
	2015-11-01
卷号	27 期号:11 页码:1628-1639
关键词	Glycoproteomics Glycoproteins Glycopeptides Nanoparticles Enrichment
ISSN号	1005-281X
DOI	10.7536/PC150513
文献子类	Review
英文摘要	As one of the most important post-translational modifications, protein glycosylation has a significant effect on the structures and functions of proteins. Many low-abundance endogenous glycoproteins/glycopeptides in the serum or tissue extracts are biomarkers with higher clinical sensitivity and specificity, which could provide valuable information to explore the pathogenesis of many diseases, discover disease biomarkers and develop proteins based new drugs. However, it is still a great challenge for glycoproteomics to selectively separate and enrich the glycoproteins/glycopeptides from the complex biological samples due to their extremely low concentrations. Nanoparticle materials have been attracted much attention in the separation and enrichment of glycoproteins/glycopeptides due to their large surface to volume ratio, numerous affinity sites and unique structures. In this work, the recent progress for the separation and enrichment of glycoproteins/glycopeptides based on the nanoparticles, including gold, SiO2, TiO2, nanodiamond and polymer nanoparticles are reviewed. Finally, the challenges and prospects for the methods of the separation and enrichment of glycoproteins/glycopeptides are briefly proposed.
WOS关键词	N-LINKED GLYCOPEPTIDES ; HIGHLY SPECIFIC ENRICHMENT ; FUNCTIONALIZED MAGNETIC NANOPARTICLES ; MASS-SPECTROMETRIC CHARACTERIZATION ; TITANIUM-DIOXIDE CHROMATOGRAPHY ; CORE-SHELL MICROSPHERES ; TOF MS ANALYSIS ; SELECTIVE ENRICHMENT ; FACILE SYNTHESIS ; MESOPOROUS SILICA
WOS研究方向	Chemistry
语种	英语
出版者	CHINESE ACAD SCIENCES
WOS记录号	WOS:000365933100010
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171576]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li Xiuling
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China 3.Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China
推荐引用方式 GB/T 7714	Ding Peng,Chen Xian,Li Xiuling,et al. The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles[J]. PROGRESS IN CHEMISTRY,2015,27(11):1628-1639.
APA	Ding Peng,Chen Xian,Li Xiuling,Qing Guangyan,Sun Taolei,&Liang Xinmiao.(2015).The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles.PROGRESS IN CHEMISTRY,27(11),1628-1639.
MLA	Ding Peng,et al."The Separation and Enrichment of Glycoproteins or Glycopeptides Based on Nanoparticles".PROGRESS IN CHEMISTRY 27.11(2015):1628-1639.