Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer

doi:10.1021/jacs.6b03924

	Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer
	Liu, Xiaogang 2,3; Qiao, Qinglong 4; Tian, Wenming 2; Liu, Wenjuan 2; Chen, Jie 2; Lang, Matthew J.1,3,5; Xu, Zhaochao 2
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2016-06-08
卷号	138 期号:22 页码:6960-6963
ISSN号	0002-7863
DOI	10.1021/jacs.6b03924
文献子类	Article
英文摘要	Replacing conventional dialkylamino substituents with a three-membered aziridine ring in naphthalimide leads to significantly enhanced brightness and photostability by effectively suppressing twisted intramolecular charge transfer formation. This replacement is generalizable in other chemical families of fluorophores, such as coumarin, phthalimide, and nitrobenzoxadiazole dyes. In highly polar fluorophores, we show that aziridinyl dyes even outperform their azetidinyl analogues in aqueous solution. We also proposed one simple mechanism that can explain the vulnerability of quantum yield to hydrogen bond interactions in protonic solvents in various fluorophore families. Such knowledge is a critical step toward developing high-performance fluorophores for advanced fluorescence imaging.
WOS关键词	LIVING CELLS ; LIVE-CELL ; MICROSCOPY ; DERIVATIVES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000377643300014
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170540]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Liu, Xiaogang; Xu, Zhaochao
作者单位	1.Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Singapore MIT Alliance Res & Technol SMART, 1 CREATE Way, Singapore 138602, Singapore 4.Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116012, Peoples R China 5.Vanderbilt Univ, Dept Chem & Biomol Engn, 221 Kirkland Hall, Nashville, TN 37235 USA
推荐引用方式 GB/T 7714	Liu, Xiaogang,Qiao, Qinglong,Tian, Wenming,et al. Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2016,138(22):6960-6963.
APA	Liu, Xiaogang.,Qiao, Qinglong.,Tian, Wenming.,Liu, Wenjuan.,Chen, Jie.,...&Xu, Zhaochao.(2016).Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,138(22),6960-6963.
MLA	Liu, Xiaogang,et al."Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 138.22(2016):6960-6963.