High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis

doi:10.1021/acs.analchem.6b01707

	High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis
	Liu, Wei 1,2; Li, Qingyun 3; Li, Haiyang 1; Wang, Shuang 1,2; Wang, Yan 1,2; Jiang, Jichun 1,2; Hua, Lei 1; Hou, Keyong 1; Xie, Yuanyuan 1; Chen, Ping 1
刊名	ANALYTICAL CHEMISTRY
	2016-09-20
卷号	88 期号:18 页码:9047-9055
ISSN号	0003-2700
DOI	10.1021/acs.analchem.6b01707
文献子类	Article
英文摘要	Photon ionization mass spectrometry (PI-MS) is a widely used technique for the online detection of trace substances to complex matrices. In this:work, a new high-pressure photon ionization (HPPI) ion source based on a vacuum ultraviolet (VUV) Kr lamp was developed for time-of-flight mass spectrometry (TOFMS). The detection sensitivity was improved by elevating thee ion source pressure to about 700 Pa. A radio frequency (RF)-only quadrupole was employed as the ion guide system following the HPPI source to: achieve high ion transmission efficiency. In-source collision induced dissociation (CID) was conducted for accurate chemical identification by varying the voltage between the ion source and the ion guide. The high humidity of the breath air can promote-the-detection of some compounds with higher ionization potentials (IPs) that could not be well detected by Single photon. ionization (SPI) at low pressure. Under 100%, relative humidity (37 degrees C), the limits of detection down to 0.015 ppbv (parts per billion by volume) for aliphatic and aromatic hydrocarbons were obtained. This HPPI-TOFMS system was preliminarily applied for online investigations of the exhaled breath from both healthy nonsmoker and smoker subjects, demonstrating its analytical capacity for complicated gases analysis. Subsequently, several frequently reported VOCs in the breath of healthy volunteers, i.e, acetone, isoprene, 2-butanone, ethanol, acetic acid, and isopropanol, were successfully identified and quantified.
WOS关键词	FLIGHT-MASS-SPECTROMETRY ; VOLATILE ORGANIC-COMPOUNDS ; COLLISION-INDUCED DISSOCIATION ; VACUUM-ULTRAVIOLET LAMP ; EXHALED BREATH ; GAS-ANALYSIS ; ION FUNNEL ; CHEMICAL-IONIZATION ; MOLECULAR-IONS ; BIOMARKERS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000384038400018
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170168]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li, Haiyang
作者单位	1.Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100039, Peoples R China 3.Jilin Univ, Dept Instrumentat & Elect Engn, Changchun 130021, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Liu, Wei,Li, Qingyun,Li, Haiyang,et al. High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis[J]. ANALYTICAL CHEMISTRY,2016,88(18):9047-9055.
APA	Liu, Wei.,Li, Qingyun.,Li, Haiyang.,Wang, Shuang.,Wang, Yan.,...&Chen, Ping.(2016).High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis.ANALYTICAL CHEMISTRY,88(18),9047-9055.
MLA	Liu, Wei,et al."High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis".ANALYTICAL CHEMISTRY 88.18(2016):9047-9055.