Plasma lipidomics reveals potential lipid markers of major depressive disorder

doi:10.1007/s00216-016-9768-5

	Plasma lipidomics reveals potential lipid markers of major depressive disorder
	Liu, Xinyu 1,2; Li, Jia 1,2; Zheng, Peng 3,4,5; Zhao, Xinjie 1; Zhou, Chanjuan 3,4,5; Hu, Chunxiu 1; Hou, Xiaoli 1; Wang, Haiyang 3,4,5; Xie, Peng 3,4,5; Xu, Guowang 1
刊名	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
	2016-09-01
卷号	408 期号:23 页码:6497-6507
关键词	Major Depressive Disorder Non-targeted Lipidomics Diagnostic Biomarker Uplc-ms
ISSN号	1618-2642
DOI	10.1007/s00216-016-9768-5
文献子类	Article
英文摘要	Major depressive disorder (MDD) is a grave debilitating mental disease with a high incidence and severely impairs quality of life. Therefore, its physiopathological basis study and diagnostic biomarker discovery are extremely valuable. In this study, a non-targeted lipidomics strategy using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) was performed to reveal differential lipids between MDD (n = 60) and healthy controls (HCs, n = 60). Validation of changed lipid species was performed in an independent batch including 75 MDD and 52 HC using the same lipidomic method. Pronouncedly changed lipid species in MDD were discovered, which mainly were lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), 1-O-alkyl-2-acyl-PE (PE O), 1-O-alkyl-2-acyl-PC (PC O), sphingomyelin (SM), diacylglycerol (DG), and triacylglycerol (TG). Among these lipid species, LPC, LPE, PC, PE, PI, TG, etc. remarkably increased in MDD and showed pronounced positive relationships with depression severity, while 1-O-alkyl-2-acyl-PE and SM with odd summed carbon number significantly decreased in MDD and demonstrated negative relationships with depression severity. A combinational lipid panel including LPE 20:4, PC 34:1, PI 40:4, SM 39:1, 2, and TG 44:2 was defined as potential diagnostic biomarker with a good sensitivity and specificity for distinguishing MDD from HCs. Our study brings insights into lipid metabolism disorder in MDD and provides a specific potential biomarker for MDD diagnose.
WOS关键词	CARDIOVASCULAR-DISEASE ; MASS-SPECTROMETRY ; HEART-DISEASE ; RAT MODEL ; BRAIN ; BIOMARKERS ; IDENTIFICATION ; TRIGLYCERIDES ; VALIDATION ; METABOLISM
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000382681900026
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170100]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Xie, Peng; Xu, Guowang
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400016, Peoples R China 4.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China 5.Chongqing Med Univ, Collaborat Innovat Ctr Brain Sci, Chongqing 400016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xinyu,Li, Jia,Zheng, Peng,et al. Plasma lipidomics reveals potential lipid markers of major depressive disorder[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2016,408(23):6497-6507.
APA	Liu, Xinyu.,Li, Jia.,Zheng, Peng.,Zhao, Xinjie.,Zhou, Chanjuan.,...&Xu, Guowang.(2016).Plasma lipidomics reveals potential lipid markers of major depressive disorder.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,408(23),6497-6507.
MLA	Liu, Xinyu,et al."Plasma lipidomics reveals potential lipid markers of major depressive disorder".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 408.23(2016):6497-6507.