Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel

doi:10.1002/jbm.a.35847

	Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel
	Lv, Shijie 4; Qiao, Qinglong 2; Zhang, Rui 5; Xiao, Jing 3; Sun, Guangwei 2; Liu, Yang 2; Zhou, Nan 2,3; Liu, Chang 1,2; Sun, Dongsheng 2
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
	2016-12-01
卷号	104 期号:12 页码:3149-3156
关键词	Gelatin-peg Hydrogel Degradation Model Response Surface Methodology Stem Cells
ISSN号	1549-3296
DOI	10.1002/jbm.a.35847
文献子类	Article
英文摘要	Gelatin hydrogel has great potential in regenerative medicine. The degradation of gelatin hydrogel is important to control the release profile of encapsulated biomolecules and regulate in vivo tissue repair process. As a plasticizer, PEG can significantly improve the mechanical property of gelatin hydrogel. However, how preparation parameters affect the degradation rate of gelatin-PEG composite hydrogel is still not clear. In this study, the significant effect factor, glutaraldehyde (GA) concentration, was confirmed by means of Plackett-Burman method. Then a mathematical model was built to predict the degradation rate of composite hydrogels under different preparation conditions using the response surface method (RSM), which was helpful to prepare the certain composite hydrogel with desired degradation rate. In addition, it was found that gelatin-PEG composite hydrogel surface well supported the adhesion and growth of human mesenchymal stem cells (MSCs). Moreover, PEG concentration not only could adjust hydrogel degradation more subtly, but also might increase the cross-linking degree and affect the cell migration. Therefore, these results would be useful to optimize the preparation of gelatin-PEG composite hydrogel for drug delivery or tissue engineering. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 3149-3156, 2016.
WOS关键词	GLUTARALDEHYDE CROSS-LINKING ; CONTROLLED-RELEASE ; BONE REGENERATION ; DELIVERY-SYSTEMS ; SCAFFOLD ; FILMS
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000386932000022
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169906]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Sun, Guangwei; Liu, Yang
作者单位	1.Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China 2.Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Dalian Med Univ, Dept Oral Pathol, Coll Stomatol, Dalian 116044, Peoples R China 4.Dalian Matern & Child Healthcare Hosp, Dalian 116033, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 1, Dept Stomatol, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Lv, Shijie,Qiao, Qinglong,Zhang, Rui,et al. Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2016,104(12):3149-3156.
APA	Lv, Shijie.,Qiao, Qinglong.,Zhang, Rui.,Xiao, Jing.,Sun, Guangwei.,...&Sun, Dongsheng.(2016).Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,104(12),3149-3156.
MLA	Lv, Shijie,et al."Degradation prediction model and stem cell growth of gelatin-PEG composite hydrogel".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104.12(2016):3149-3156.