Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications

doi:10.1039/c6ra24954j

	Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications
	Zhang, Fengxiang 1; Li, Lingdong 1; Zhou, Hao 2; Gai, Fangyuan 1; Chi, Xiaofang 1; Zhao, Yuebiao 1; Zhao (Kent), Zongbao 3
刊名	RSC ADVANCES
	2017
卷号	7 期号:22 页码:13244-13249
ISSN号	2046-2069
DOI	10.1039/c6ra24954j
文献子类	Article
英文摘要	The recently developed quaternary ammonium (QA) N-chloramine has been proved to be a promising "composite" biocide with drastically boosted antibacterial efficacy afforded by the QA moiety. In this work, a series of quaternary phosphonium (QP) N-chloramine biocides, covalently combining an N-chloramine moiety and a QP moiety via varied aliphatic methylene units, were synthesized by means of multi-step chemical reactions. Preliminary antibacterial tests against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) showed that the synthetic QP N-chloramine exhibited distinctively higher biocidal efficacy than the QA counterpart. Furthermore, bactericidal tests also indicated that QP N-chloramine with a linker of -(CH2)(12)-showed the highest biocidal efficacy, suggesting synergistic action between the N-chloramine moiety and QP moiety.
WOS关键词	HALAMINE POLYMERIC BIOCIDES ; AMMONIUM MOIETIES ; BACTERIA ; CELLULOSE ; DISINFECTANTS ; NANOPARTICLES ; ELUCIDATION ; MECHANISMS ; FABRICS ; SALT
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000395935300027
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169514]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li, Lingdong
作者单位	1.Dalian Univ Technol, State Key Lab Fine Chem, Sch Chem & Petr Engn, 2 Dagong Rd, Liaodongwan New Dist 124221, Panjin, Peoples R China 2.Dalian Univ Technol, Sch Food & Environm, 2 Dagong Rd, Liaodongwan New Dist 124221, Panjin, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fengxiang,Li, Lingdong,Zhou, Hao,et al. Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications[J]. RSC ADVANCES,2017,7(22):13244-13249.
APA	Zhang, Fengxiang.,Li, Lingdong.,Zhou, Hao.,Gai, Fangyuan.,Chi, Xiaofang.,...&Zhao .(2017).Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications.RSC ADVANCES,7(22),13244-13249.
MLA	Zhang, Fengxiang,et al."Synthesis of quaternary phosphonium N-chloramine biocides for antimicrobial applications".RSC ADVANCES 7.22(2017):13244-13249.