Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles | |
Li, Guohui3; Wang, Zheng1,2,5; Zhao, Yanjun1,2,5; Gao, Min1,2; Deng, Jian1,2; Chu, Huiying3; Tang, Yu4 | |
刊名 | BIOMACROMOLECULES |
2017-12-01 | |
卷号 | 18期号:12页码:4349-4356 |
ISSN号 | 1525-7797 |
DOI | 10.1021/acs.biomac.7b01409 |
文献子类 | Article |
英文摘要 | Vitamin E (alpha-tocopherol; TPGS) micelle is a robust nanocarrier in delivering hydrophobic active pharmaceutical ingredients, but it is suffering from poor stability that is essential in terms of pharmaceutical and biomedical applications. Taking advantage of the chirality of vitamin E, this work reports the stereoselective stabilization of polymer-vitamin E conjugate micelles. Vitamin E was covalently linked to multivalent methoxy poly(ethylene glycol)-co-poly(glutamic acid), generating amphiphilic conjugates that could self-assemble into micelles. Eight types of micelles were produced via tailored combination of polymer backbone and side chain with different chirality. The particle size and critical micelle concentration analysis demonstrated a correlation between conjugate chirality and micelle stability. The most stable micelles were obtained when poly(glutamic acid) and vitamin E both are dextrorotatory, because of the high degree of alpha-helix revealed by both circular dichroism spectroscopy and molecular dynamics simulation. This phenomenon was further verified by the fluorescence resonance energy transfer (FRET) analysis in HepG2 cells. The current work not only provides a method to enhance the stability of vitamin E micelles, but also adds an additional facile tool in regulating the stability of polymer conjugate micelles without changing the conjugate composition. |
WOS关键词 | ALPHA-HELICAL POLYPEPTIDES ; ANTICANCER DRUG-DELIVERY ; SIDE-CHAIN ; STABILITY ; ARCHITECTURE ; CHIRALITY ; CURCUMIN ; RELEASE ; ACID) |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000418109200049 |
内容类型 | 期刊论文 |
源URL | [http://cas-ir.dicp.ac.cn/handle/321008/169204] |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
通讯作者 | Li, Guohui; Zhao, Yanjun |
作者单位 | 1.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China 2.Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Lab Mol Modeling & Design, 457 Zhongshan Rd, Dalian 116023, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, 5 Yunshan Rd, Qingdao 266003, Peoples R China 5.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Guohui,Wang, Zheng,Zhao, Yanjun,et al. Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles[J]. BIOMACROMOLECULES,2017,18(12):4349-4356. |
APA | Li, Guohui.,Wang, Zheng.,Zhao, Yanjun.,Gao, Min.,Deng, Jian.,...&Tang, Yu.(2017).Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles.BIOMACROMOLECULES,18(12),4349-4356. |
MLA | Li, Guohui,et al."Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles".BIOMACROMOLECULES 18.12(2017):4349-4356. |
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