Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure

doi:10.1016/j.scitotenv.2017.11.304

	Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure
	Ren, Xiaodian 1,2; Zhang, Haijun 2; Geng, Ningbo 2; Xing, Liguo 3; Zhao, Yu 3; Wang, Feidi 1,2; Chen, Jiping 2
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2018-05-01
卷号	622 页码:214-221
关键词	Short-chain Chlorinated Paraffins Zebrafish Embryo/larvae Metabolomics Developmental Toxicity
ISSN号	0048-9697
DOI	10.1016/j.scitotenv.2017.11.304
文献子类	Article
英文摘要	Short-chain chlorinated paraffins (SCCPs) are highly toxic to aquatic organisms, but their toxicity is yet not well characterized. In this study, the developmental toxicity of SCCPs to zebrafish embryos/larvae was evaluated, and a metabolomics approach was adopted to explore the impact of SCCPs exposure on the metabolismin zebrafish embryos. Exposure to SCCPs at concentrations of 1-200 mu g/L did not produce an observable effect on the hatching rate andmorphological deformities of zebrafish embryos/ larvae. However, the survival rate of zebrafish larvae in SCCPs exposure groups decreased in a concentration-dependent manner. The 13-day 50% lethal concentration (LC50) value of SCCPs was calculated to be 34.4 mu g/L. Exposure to SCCPs induced a significant change of overall metabolism, even at environmentally relevant concentrations (1-5 mu g/L). The most relevant pathways affected by SCCPs exposure were glycerophospholipid metabolism, fatty acid metabolism and purine metabolism. Exposure to SCCPs at concentrations of 1-5 mu g/L had begun to accelerate the beta-oxidation of unsaturated fatty acids and very long chain fatty acids, and affect the transformation of guanine to xanthine in the pathway of purinemetabolism. Furthermore, when the exposure concentrations of SCCPs were increased to 50-200 mu g/L, the levels of phospholipids and amino acids were significantly raised; whereas the levels of fatty acids, carnitines and inosine were significantly decreased. In view of the significant effect on metabolism, the sub-chronic and chronic toxicity of SCCPs to fish should be concerned. (C) 2017 Elsevier B.V. All rights reserved.
WOS关键词	RETINAL GANGLION-CELLS ; N-ALKANES ; PURINE METABOLISM ; MASS-SPECTROMETRY ; TROPHIC TRANSFER ; BOHAI SEA ; BIOACCUMULATION ; INOSINE ; LYSOPHOSPHATIDYLCHOLINE ; DEREGULATION
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000426349000024
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/168840]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhang, Haijun; Chen, Jiping
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Shenyang Res Inst Chem Ind Ltd, Safety Evaluat Ctr, Shenyang 110021, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ren, Xiaodian,Zhang, Haijun,Geng, Ningbo,et al. Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,622:214-221.
APA	Ren, Xiaodian.,Zhang, Haijun.,Geng, Ningbo.,Xing, Liguo.,Zhao, Yu.,...&Chen, Jiping.(2018).Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure.SCIENCE OF THE TOTAL ENVIRONMENT,622,214-221.
MLA	Ren, Xiaodian,et al."Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure".SCIENCE OF THE TOTAL ENVIRONMENT 622(2018):214-221.