A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)

doi:10.1016/j.envpol.2017.11.073

	A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)
	Wang, Feidi 1,2; Zhang, Haijun 1; Geng, Ningbo 1; Ren, Xiaoqian 1,2; Zhang, Baoqin 1; Gong, Yufeng 1; Chen, Jiping 1
刊名	ENVIRONMENTAL POLLUTION
	2018-03-01
卷号	234 页码:572-580
关键词	Combined Toxicity Metabolomics Polycyclic Aromatic Hydrocarbons Short-chain Chlorinated Paraffins
ISSN号	0269-7491
DOI	10.1016/j.envpol.2017.11.073
文献子类	Article
英文摘要	The combined toxicity of mixed chemicals is usually evaluated according to several specific endpoints, and other potentially toxic effects are disregarded. In this study, we provided a metabolomics strategy to achieve a comprehensive understanding of toxicological interactions between mixed chemicals on metabolism. The metabolic changes were quantified by a pseudotargeted analysis, and the types of combined effects were quantitatively discriminated according to the calculation of metabolic effect level index (MELI). The metabolomics strategy was used to assess the combined effects of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs) on the metabolism of human hepatoma HepG2 cells. Our data suggested that exposure to a combination of PAHs and SCCPs at human internal exposure levels could result in an additive effect on the overall metabolism, whereas diverse joint effects were observed on various metabolic pathways. The combined exposure could induce a synergistic up-regulation of phospholipid metabolism, an additive up -regulation of fatty acid metabolism, an additive down-regulation of tricarboxylic acid cycle and glycolysis, and an antagonistic effect on purine metabolism. SCCPs in the mixture acted as the primary driver for the acceleration of phospholipid and fatty acid metabolism. Lipid metabolism disorder caused by exposure to a combination of PAHs and SCCPs should be an important concern for human health. (C) 2017 Elsevier Ltd. All rights reserved.
WOS关键词	ENVIRONMENTAL RISK-ASSESSMENT ; HEPG2 CELLS ; N-ALKANES ; EXPOSURE ; MECHANISM ; BLOOD ; LIVER ; MILK ; PERSPECTIVE ; METABOLISM
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000426225100060
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/168678]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhang, Haijun
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Feidi,Zhang, Haijun,Geng, Ningbo,et al. A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)[J]. ENVIRONMENTAL POLLUTION,2018,234:572-580.
APA	Wang, Feidi.,Zhang, Haijun.,Geng, Ningbo.,Ren, Xiaoqian.,Zhang, Baoqin.,...&Chen, Jiping.(2018).A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs).ENVIRONMENTAL POLLUTION,234,572-580.
MLA	Wang, Feidi,et al."A metabolomics strategy to assess the combined toxicity of polycyclic aromatic hydrocarbons (PAHs) and short-chain chlorinated paraffins (SCCPs)".ENVIRONMENTAL POLLUTION 234(2018):572-580.