Fluorescence Spectroscopic Insight into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation

doi:10.1002/cbic.201800393

	Fluorescence Spectroscopic Insight into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation
	Jia, Guoqing 1; Cheng, Yu 1,2; Cheng, Mingpan 1,2; Hao, Jingya 1,2; Li, Can 1
刊名	CHEMBIOCHEM
	2018-10-18
卷号	19 期号:20 页码:2233-2240
关键词	DNA catalysis enantioselectivity fluorescence G-quadruplexes molecular recognition sulfoxidation
ISSN号	1439-4227
DOI	10.1002/cbic.201800393
通讯作者	Li, Can(canli@dicp.ac.cn)
英文摘要	Interactions of copper(II)-bipyridine cofactors and thioanisole substrate with human telomeric G-quadruplex DNA were studied by UV/Vis absorption, circular dichroism, and fluorescence quenching titration. Three copper(II)-bipyridine complexes are equivalently anchored to the G-quadruplex scaffold at all five fluorescently labeled sites. Thioanisole interacts with the DNA architecture at both the second loop and 3 terminus in the absence or presence of copper(II)-bipyridine complexes. These nonspecificities in the weak interactions of Cu-II complexes and thioanisole with G-quadruplex might explain why DNA only affords a modest enantioselectivity in the oxidation of thioanisole. These findings provide insights toward the construction of highly enantioselective DNA-based catalysts.
资助项目	National Natural Science Foundation of China[21227801] ; Natural Science Foundation of Liaoning Province[2015020700]
WOS关键词	DIELS-ALDER REACTION ; G-QUADRUPLEX DNA ; ASYMMETRIC CATALYSIS ; BINDING-SITE ; RATE ACCELERATION ; HYBRID CATALYSIS ; DNAZYME ; WATER ; SUBSTRATE ; METALLOENZYME
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000447635300015
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Liaoning Province
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166844]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li, Can
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Dept Chem Phys, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Jia, Guoqing,Cheng, Yu,Cheng, Mingpan,et al. Fluorescence Spectroscopic Insight into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation[J]. CHEMBIOCHEM,2018,19(20):2233-2240.
APA	Jia, Guoqing,Cheng, Yu,Cheng, Mingpan,Hao, Jingya,&Li, Can.(2018).Fluorescence Spectroscopic Insight into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation.CHEMBIOCHEM,19(20),2233-2240.
MLA	Jia, Guoqing,et al."Fluorescence Spectroscopic Insight into the Supramolecular Interactions in DNA-Based Enantioselective Sulfoxidation".CHEMBIOCHEM 19.20(2018):2233-2240.