Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces

doi:10.1038/s41467-018-06869-9

	Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
	Dong, Jun 1; Cai, Xiaoming 4; Liu, Jing 6; Zheng, Huizhen 4; Kaweeteerawat, Chitrada 2; Wang, Fangjun 6; Ji, Zhaoxia 3,5; Li, Ruibin 4
刊名	NATURE COMMUNICATIONS
	2018-10-24
卷号	9 页码:12
ISSN号	2041-1723
DOI	10.1038/s41467-018-06869-9
通讯作者	Ji, Zhaoxia(zji@cnsi.ucla.edu) ; Li, Ruibin(liruibin@suda.edu.cn)
英文摘要	Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views on ENM-induced bio-effects. Here we report a multi-hierarchical nano-SAR assessment for a representative ENM, Fe2O3, by metabolomics and proteomics analyses. The established nano-SAR profile allows the visualizing of the contributions of seven basic properties of Fe2O3 to its diverse bio-effects. For instance, although surface reactivity is responsible for Fe2O3-induced cell migration, the inflammatory effects of Fe2O3 are determined by aspect ratio (nanorods) or surface reactivity (nanoplates). These nano-SARs are examined in THP-1 cells and animal lungs, which allow us to decipher the detailed mechanisms including NLRP3 inflammasome pathway and monocyte chemoattractant protein-1-dependent signaling. This study provides more insights for nano-SARs, and may facilitate the tailored design of ENMs to render them desired bio-effects.
资助项目	National Natural Science Foundation of China[31671032] ; National Natural Science Foundation of China[21804096] ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province[17KJA310003] ; Natural Science Foundation of Jiangsu Province[BK20180840] ; Suzhou Science and Technology Development Project[SYS201715] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
WOS关键词	OXIDATIVE STRESS ; OXIDE NANOPARTICLES ; PULMONARY TOXICITY ; TUMOR-GROWTH ; BAND-GAP ; IN-VITRO ; CELLS ; PROTEIN ; MIGRATION ; SPECTROSCOPY
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000448104800005
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Key Project of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Province ; Suzhou Science and Technology Development Project ; Suzhou Science and Technology Development Project ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166804]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ji, Zhaoxia; Li, Ruibin
作者单位	1.Wuhan Acad Agr Sci, Wuhan 430000, Hubei, Peoples R China 2.NSTDA, Natl Nanotechnol Ctr NANOTEC, Klong Nueng 12120, Thailand 3.Living Proof Inc, Cambridge, MA 02142 USA 4.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Publ Hlth,Sch Radiat Med & Protect, Collaborat Innovat Ctr Radiol Med,Jiangsu Higher, Suzhou 215123, Jiangsu, Peoples R China 5.Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA 6.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Dong, Jun,Cai, Xiaoming,Liu, Jing,et al. Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces[J]. NATURE COMMUNICATIONS,2018,9:12.
APA	Dong, Jun.,Cai, Xiaoming.,Liu, Jing.,Zheng, Huizhen.,Kaweeteerawat, Chitrada.,...&Li, Ruibin.(2018).Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces.NATURE COMMUNICATIONS,9,12.
MLA	Dong, Jun,et al."Multi-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces".NATURE COMMUNICATIONS 9(2018):12.