The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China

doi:10.2147/CMAR.S195351

	The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China
	Lin, Wenchu 2,3; Wu, Haibo 1; Wang, Wei 2,3; Du, Jun 1; Li, Hong 2,3; Wang, Huogang 2,3; Huang, Liangliang 1; Xiang, Hang 2,3; Xie, Jing 1; Liu, Xiaoli 2,3
刊名	CANCER MANAGEMENT AND RESEARCH
	2019
卷号	11 页码:1473-1492
关键词	breast cancer PIK3CA clinicopathological characteristics prognosis
ISSN号	1179-1322
DOI	10.2147/CMAR.S195351
通讯作者	Lin, Wenchu(wenchu@hmfl.ac.cn)
英文摘要	Purpose: The mutation status and prognostic value of PIK3CA in breast cancer were widely investigated, which showed significant difference among the patients from vast areas around the world. In this study, the frequency, distribution, bias, and burden of PIK3CA mutations and their relationships with clinicopathologic variables and prognostic significances were investigated in the breast cancer patients from Central China. Materials and methods: Somatic mutations in exon 9 and exon 20 of PIK3CA gene were analyzed using Sanger sequencing combining with targeted next generation sequencing in 494 breast cancer patients from Central China. The correlations between PIK3CA mutations and clinicopathological characteristics and the prognostic values of multiple PIK3CA mutation statuses were evaluated. Results: PIK3CA mutations were found in 38% of the patients and associated with estrogen receptor-positive, progesterone receptor-positive, low Ki67 labeling index, and luminal/human epidermal growth factor receptor 2-enriched subtypes. Meanwhile, the prognosis of the total patients and the patients in old diagnostic age, progesterone receptor-negative, low Ki67 labeling index, and luminal/human epidermal growth factor receptor 2-enriched subgroups was significantly related to PIK3CA mutations. Most interestingly, the distribution, bias, and burden of PIK3CA mutations were correlated with different clinical, pathological, and molecular features as well as distinct prognostic implications in multiple breast cancer subgroups. Conclusion: The frequency, distribution, bias, and burden of PIK3CA mutations were associated with various clinical, pathological, and molecular characteristics in the breast cancer patients from Central China. These different mutation statuses can be used as potential indicators of prognosis in multiple breast cancer subgroups.
资助项目	National Natural Science Foundation of China[81702954] ; National Natural Science Foundation of China[81372214] ; Key Technologies R&D Programme of Anhui Province[1604a0802103] ; Fundamental Research Funds for the Central Universities[WK9110000042] ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX006] ; 100-Talent Program of Chinese Academy of Sciences
WOS关键词	INTERNATIONAL EXPERT CONSENSUS ; NEOADJUVANT CHEMOTHERAPY ; PRIMARY THERAPY ; HIGH-FREQUENCY ; GENE ; PATHWAY ; ASSOCIATION ; CARCINOMAS ; ROLES ; WOMEN
WOS研究方向	Oncology
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000458907200001
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/165994]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Lin, Wenchu
作者单位	1.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp 1, Dept Pathol, Hefei 230036, Anhui, Peoples R China 2.Chinese Acad Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Lin, Wenchu,Wu, Haibo,Wang, Wei,et al. The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China[J]. CANCER MANAGEMENT AND RESEARCH,2019,11:1473-1492.
APA	Lin, Wenchu.,Wu, Haibo.,Wang, Wei.,Du, Jun.,Li, Hong.,...&Li, Heng.(2019).The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China.CANCER MANAGEMENT AND RESEARCH,11,1473-1492.
MLA	Lin, Wenchu,et al."The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from Central China".CANCER MANAGEMENT AND RESEARCH 11(2019):1473-1492.