Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer

doi:10.1021/acs.analchem.8b04168

	Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer
	Wang, Shuang 2,3; Wang, Weimin 2,3; Li, Hong 1; Xing, Yuming 1; Hou, Keyong 3; Li, Haiyang 3
刊名	ANALYTICAL CHEMISTRY
	2019-03-19
卷号	91 期号:6 页码:3845-3851
ISSN号	0003-2700
DOI	10.1021/acs.analchem.8b04168
通讯作者	Hou, Keyong(houky@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
英文摘要	Illegal drug smugglings and crimes have long been a global concern, and an apparatus which can identify drugs on-the-spot is urgently demanded by law enforcement. A thermal desorption acetone-assisted photoionization miniature ion trap mass spectrometer was developed for on-site and rapid identification of illegal drugs at checkpoints. Acetone was chosen for dopant-assisted photoionization, and the sensitivity of selected drugs was further enhanced with protonated analyte molecular ions [M + H](+). For example, the sensitivity of ephedrine was improved by as high as 22-fold. The mass discrimination effect, which was usually considered as a shortcoming of ion trap mass analyzer, was ingeniously utilized to eliminate the protonated acetone reagent ions and maximize the trapping efficiency of analyte ions in mass analyzer. Twenty-seven drugs were analyzed, and the limits of detection (LODs) of selected illegal drugs were at the nanogram level with analysis time of 2 s. Analyte/dopant ion peak intensity ratios in mass spectra could be used for quantitation to improve the quantitative analysis performance of miniature ion trap mass spectrometer equipped with a discontinuous atmospheric pressure interface (DAPI) with the prerequisite that dopant ions and analyte ions could be simultaneously and effectively trapped by the ion trap. The RSD of signal intensity was reduced from 25.3% to 8.5%, and the linear range was extended from 0.5-25 to 0.5-100 ng/mu L for methamphetamine. A temperature-resolved thermal desorption sampling strategy was developed and used to distinguish illegal drug components in plant-based drug samples and drinks containing illegal drugs.
资助项目	National Natural Science Foundation of China[21675155] ; National Key Research and Development Program of China[2016YFC0800902] ; DICP[DICP ZZBS201701]
WOS关键词	ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; MOBILITY SPECTROMETRY ; AMBIENT IONIZATION ; RAMAN-SPECTROSCOPY ; CROSS-SECTIONS ; CANNABINOIDS ; PERFORMANCE ; PEOPLE ; ABUSE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000462098300014
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/165712]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Hou, Keyong; Li, Haiyang
作者单位	1.Yunnan Police Officer Acad, 249 Jiaochang North Rd, Kunming 650223, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shuang,Wang, Weimin,Li, Hong,et al. Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer[J]. ANALYTICAL CHEMISTRY,2019,91(6):3845-3851.
APA	Wang, Shuang,Wang, Weimin,Li, Hong,Xing, Yuming,Hou, Keyong,&Li, Haiyang.(2019).Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer.ANALYTICAL CHEMISTRY,91(6),3845-3851.
MLA	Wang, Shuang,et al."Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer".ANALYTICAL CHEMISTRY 91.6(2019):3845-3851.