Glycerolipid remodeling triggered by phosphorous starvation and recovery in Nannochloropsis oceanica

doi:10.1016/j.algal.2019.101451

	Glycerolipid remodeling triggered by phosphorous starvation and recovery in Nannochloropsis oceanica
	Meng, Yingying 1,2; Cao, Xupeng 1; Yang, Miao 1; Liu, Jiao 1,3; Yao, Changhong 4; Xue, Song 1
刊名	ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
	2019-05-01
卷号	39 页码:9
关键词	Glycerolipid remodeling Lipidomic analysis Phosphorous limitation and recovery Nannochloropsis oceanica DGTS
ISSN号	2211-9264
DOI	10.1016/j.algal.2019.101451
通讯作者	Xue, Song(xuesong@dicp.ac.cn)
英文摘要	To understand the function of DGTS (diacylglyceryl-N,N,N-trimethyl-homoserine) as substitution of PC (phosphatidylcholine), Nannochloropsis oceanica has been chosen as the model system because it has DGTS and PC simultaneously. Phosphorus is a regulator for DGTS and PC. Generally, DGTS increases and correspondingly PC decreases under phosphorous starvation. However, the function of DGTS and its fatty acid origin under phosphorous starvation, and the resurgence of PC triggered by phosphorus recovery remain not clarified completely. In the present study, we investigated the effect of phosphorus starvation and recovery on polar glycerolipid remodeling in N. oceanica based on quantitative lipidomic data. Through targeted lipidomics analysis, we proposed that, under phosphorus deprivation, DGTS serves as the central intermediate in glycerolipid remodeling via acting as the carrier of the C18 fatty acids desaturation by replacement of PC, maintaining the biosynthesis of EPA (eicosapentaenoic acid) and providing the EPA acyl as a precursor for formation of chloroplast glycolipids. The prokaryotic molecular species of DGTS are mainly from de novo biosynthesis pathway and make the major contribution for the DGTS increase. In the process of resupplying phosphorus, PC increased attributing to hydrolysis of TAG, generating diacylglycerol for PC biosynthesis. These new information demonstrated that DGTS and PC varied conversely in different metabolic pathways as revealed by targeted lipidomic data.
资助项目	China Postdoctoral Science Foundation[2018M632709] ; National High-tech R&D Program (863 Program)[2012AA052101]
WOS关键词	MICROALGA TETRASELMIS-SUBCORDIFORMIS ; FATTY-ACID-COMPOSITION ; CHLAMYDOMONAS-REINHARDTII ; PHOSPHATE STARVATION ; NITROGEN DEPRIVATION ; STARCH PRODUCTION ; ACCUMULATION ; LIPIDS ; TRIACYLGLYCEROL ; BIOSYNTHESIS
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000467066000029
资助机构	China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National High-tech R&D Program (863 Program) ; National High-tech R&D Program (863 Program) ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National High-tech R&D Program (863 Program) ; National High-tech R&D Program (863 Program) ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National High-tech R&D Program (863 Program) ; National High-tech R&D Program (863 Program) ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National High-tech R&D Program (863 Program) ; National High-tech R&D Program (863 Program)
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/165464]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Xue, Song
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioengn Grp, Dalian 116023, Peoples R China 2.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Shandong, Peoples R China 3.Qilu Univ Technol, Dept Bioengn, Jinan 250353, Shandong, Peoples R China 4.Sichuan Univ, Sch Chem Engn, Dept Pharmaceut & Biol Engn, Chengdu 610065, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Meng, Yingying,Cao, Xupeng,Yang, Miao,et al. Glycerolipid remodeling triggered by phosphorous starvation and recovery in Nannochloropsis oceanica[J]. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,2019,39:9.
APA	Meng, Yingying,Cao, Xupeng,Yang, Miao,Liu, Jiao,Yao, Changhong,&Xue, Song.(2019).Glycerolipid remodeling triggered by phosphorous starvation and recovery in Nannochloropsis oceanica.ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS,39,9.
MLA	Meng, Yingying,et al."Glycerolipid remodeling triggered by phosphorous starvation and recovery in Nannochloropsis oceanica".ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS 39(2019):9.