Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection

	Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection
	Kang, Yanjun ; Wu, Yi-Zhou ; Hu, Xianyun ; Xu, Xueqin ; Sun, Jie ; Geng, Rong ; Huang, Tongxing ; Liu, Xiaohang ; Ma, Yichen ; Chen, Ying ; Wan, Quan ; Qi, Xiaobang ; Zhang, Gen ; Zhao, Xiaohui ; Zeng, Xin
刊名	SCIENTIFIC REPORTS
	2017-03-27
英文摘要	Because they generate excellent images, nanoparticles (NPs), especially biosynthesized NPs, provide a new solution for tumor imaging. In this research, we unveil a novel type of biosynthesized NPs featuring multicolor fluorescence. These NPs exhibit little cytotoxicity to cells. The explored NPs, designated ZnZFP- GST NPs (Zinc NPs in abbreviation), are generated from leukemia cells treated with a Zn2+ solution, while zinc-finger protein and glutathione S-transferase (GST) were also identified in the Zinc NPs. Under near-UV illumination, the Zinc NPs simultaneously emit green, yellow, and red fluorescence. In addition, the intensity of the fluorescence increases with the existence of sulfides. Besides, the NPs are encapsulated by microvesicles (MVs) shed from the plasma membrane. As observed in wholebody research of nude mice, the NP-MVs migrate via blood circulation and are distinguished by their fluorescent signals. Furthermore, the folic acid (FA) & AVR2 (human VEGF antibody)-coated NP-MVs are exploited to target the tumor location, and the feasibility of this approach has been confirmed empirically. The Zinc NPs shed light on an alternative solution to tumor detection.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6796]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Kang, Yanjun,Wu, Yi-Zhou,Hu, Xianyun,et al. Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection[J]. SCIENTIFIC REPORTS,2017.
APA	Kang, Yanjun.,Wu, Yi-Zhou.,Hu, Xianyun.,Xu, Xueqin.,Sun, Jie.,...&Zeng, Xin.(2017).Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection.SCIENTIFIC REPORTS.
MLA	Kang, Yanjun,et al."Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection".SCIENTIFIC REPORTS (2017).