Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet

	Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet
	Cai, Zhenyuan ; Wang, Liuyang ; Song, Xiaoying ; Tagore, Somnath ; Li, Xiangfeng ; Wang, Huihua ; Chen, Jiarui ; Li, Kexin ; Frenkel, Zeev ; Gao, Dahai ; Frenkel-Morgenstern, Milana ; Zhang, Tongzuo ; Nevo, Eviatar
刊名	SCIENTIFIC REPORTS
	2018-03-16
英文摘要	Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes of zokors from three populations with distinct altitudes and ecologies (Low: 2846 m, Middle: 3282 m, High: 3,714 m) were sequenced and compared. Phylogenetic and principal component analyses classified them into three divergent altitudinal population clusters. Genetic polymorphisms showed that the population at H, approaching the uppermost species boundary, harbors the highest genetic polymorphism. Moreover, 1056 highly up-regulated UniGenes were identified from M to H. Gene ontologies reveal genes like EPAS1 and COX1 were overexpressed under hypoxia conditions. EPAS1, EGLN1, and COX1 were convergent in high-altitude adaptation against stresses in other species. The fixation indices (FST and GST)-based outlier analysis identified 191 and 211 genes, highly differentiated among L, M, and H. We observed adaptive transcriptome changes in Myospalax baileyi, across a few hundred meters, near the uppermost species boundary, regardless of their relatively stable underground burrows' microclimate. The highly variant genes identified in Myospalax were involved in hypoxia tolerance, hypercapnia tolerance, ATP-pathway energetics, and temperature changes.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/13344]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Cai, Zhenyuan,Wang, Liuyang,Song, Xiaoying,et al. Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet[J]. SCIENTIFIC REPORTS,2018.
APA	Cai, Zhenyuan.,Wang, Liuyang.,Song, Xiaoying.,Tagore, Somnath.,Li, Xiangfeng.,...&Nevo, Eviatar.(2018).Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.SCIENTIFIC REPORTS.
MLA	Cai, Zhenyuan,et al."Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet".SCIENTIFIC REPORTS (2018).