Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau

	Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau
	Tong, Chao ; Tian, Fei ; Tang, Yongtao ; Feng, Chenguang ; Guan, Lihong ; Zhang, Cunfang ; Zhao, Kai
刊名	FISH & SHELLFISH IMMUNOLOGY
	2016-03-01
英文摘要	Tibetan Plateau (TP) had experienced phased uplift, resulting in inhospitable environment of low temperature, hypoxia and high ultraviolet radiation for Tibetan wildlife. Many organisms can well adapt to TP, it is of ecological and evolutionary interest to untangle how organisms adapt to extreme environment on TP through evolution. Previous studies mainly focused on hypoxia and metabolism related genes, but we know little about the evolutionary history of immune genes in Tibetan wildlife. In this study, we first identified 10 interferon regulatory factor (IRF) genes from Tibetan naked carp Gymnocypris przewalskii. Within this gene family, IRF3, IRF5, IRF7 and IRF8 contained positive selection sites. Evidences indicated that positive selection may lead to IRF genes functional alternations, presumably driving genes towards adaptation to the environmental changes. Taken together, our results suggested 4 candidate genes as interesting targets for further experimental confirmation of their functional variations and contributions to high altitude adaptation in Tibet fish. (C) 2016 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/5733]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Tong, Chao,Tian, Fei,Tang, Yongtao,et al. Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau[J]. FISH & SHELLFISH IMMUNOLOGY,2016.
APA	Tong, Chao.,Tian, Fei.,Tang, Yongtao.,Feng, Chenguang.,Guan, Lihong.,...&Zhao, Kai.(2016).Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau.FISH & SHELLFISH IMMUNOLOGY.
MLA	Tong, Chao,et al."Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau".FISH & SHELLFISH IMMUNOLOGY (2016).