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	Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression
	Han, Yanjiang1,2; Yin, Duanzhi1; Zheng, Mingqiang1; Zhou, Wei1; Lee, ZhenHong; Zhan, Lan1; Ma, Yufei1; Wu, Mingxing1; Shi, Lingli1; Wang, Ni1
刊名	Journal of radioanalytical and nuclear chemistry
	2010-05-01
卷号	284期号:2页码:279-286
关键词	Cxcr4 Sdf-1 Sib Radioiodination
ISSN号	0236-5731
DOI	10.1007/s10967-010-0484-x
通讯作者	Wang, yongxian(yongxianw@163.com)
英文摘要	The aim of this study was to develop a radiopharmaceutical for the imaging of cxcr4-expressing tumors in vivo. for i-125-labeling, i-125-sib was synthesized and conjugated with the epsilon-nh2 group of ac-tz14011, a specific cxcr4 antagonist. the specific radioactivity of the product was 5 gbq/mu mol and the radiochemical purity (rcp) was 96% (n = 3). after 6 h, the rcp of the product in pbs was 93%. the mcf-7 cell uptake of ac-tz14011 was rapid and high. primary biodistribution studies indicated that i-125-ib-ac-tz14011 was mainly excreted via the kidney, and further evaluation in mice with induced tumors was necessary.
WOS关键词	GROWTH-STIMULATING FACTOR ; BREAST-CANCER METASTASIS ; N-SUCCINIMIDYL ; CHEMOKINE RECEPTORS ; MOLECULAR-CLONING ; PERIPHERAL-BLOOD ; CELLS ; ENTRY ; SDF-1 ; BONE
WOS研究方向	Chemistry ; Nuclear Science & Technology
WOS类目	Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000276910000004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2413122
专题	中国科学院大学
通讯作者	Wang, Yongxian
作者单位	1.Chinese Acad Sci, Res Ctr Radiopharmaceut, Shanghai Inst Appl Phys, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Case Western Reserve Univ, Dept Nucl Med Radiol, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA
推荐引用方式 GB/T 7714	Han, Yanjiang,Yin, Duanzhi,Zheng, Mingqiang,et al. Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression[J]. Journal of radioanalytical and nuclear chemistry,2010,284(2):279-286.
APA	Han, Yanjiang.,Yin, Duanzhi.,Zheng, Mingqiang.,Zhou, Wei.,Lee, ZhenHong.,...&Wang, Yongxian.(2010).Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression.Journal of radioanalytical and nuclear chemistry,284(2),279-286.
MLA	Han, Yanjiang,et al."Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression".Journal of radioanalytical and nuclear chemistry 284.2(2010):279-286.

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