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	Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats
	Wang, Lijuan; Wang, Lin; Ding, Wenjun; Zhang, Fang
刊名	Journal of nanoscience and nanotechnology
	2010-12-01
卷号	10期号:12页码:8617-8624
关键词	Acute toxicity Nanoscale fe2o3 Nanoscale zno Rats
ISSN号	1533-4880
DOI	10.1166/jnn.2010.2483
通讯作者	Ding, wenjun()
英文摘要	We investigated the toxic effects of inhalation exposure to ferric oxide (fe2o3) and zinc oxide (zno) nanoparticles in rats. male wistar rats were consecutively treated with fe2o3 at 8.5 mg/kg body weight and zno nanoparticles at 2.5 mg/kg body weight, twice daily for 3 days. content of fe2o3 and zno in tissues, biochemical parameters in serum, and hispathological examinations were analyzed at 12 h and 36 h after the 3 day treatment. in the fe2o3-treated group, iron (fe) content in liver and lung tissues was significantly increased at 36 h. in the zno-treated group, zinc (zn) content in liver tissues was significantly increased at 12 h and further increased at 36 h. the levels of serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), total protein (tp), creatine kinase (ck), and lactate dehydrogenase (ldh) in both nanoparticle-exposed groups were significantly decreased compared to the unexposed controls. histopathological examination showed that both types of nanoparticles caused severe damage in liver and lung tissues. although this damage progressed in both liver and lung throughout the post-exposure period, no significant elevation of serum enzyme activities was observed in response to either nanoparticle type.
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000283621400101
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2412883
专题	中国科学院大学
通讯作者	Ding, Wenjun
作者单位	Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lijuan,Wang, Lin,Ding, Wenjun,et al. Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats[J]. Journal of nanoscience and nanotechnology,2010,10(12):8617-8624.
APA	Wang, Lijuan,Wang, Lin,Ding, Wenjun,&Zhang, Fang.(2010).Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats.Journal of nanoscience and nanotechnology,10(12),8617-8624.
MLA	Wang, Lijuan,et al."Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats".Journal of nanoscience and nanotechnology 10.12(2010):8617-8624.

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