| Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes | |
| Qu, Hongzhu1,2; Wu, Hao1,3; Zhang, Tongwu1,3; Zhang, Zhang4; Hu, Songnian1; Yu, Jun1,4 | |
| 刊名 | Research in microbiology
 |
| 2010-12-01 | |
| 卷号 | 161期号:10页码:838-846 |
| 关键词 | Nucleotide composition asymmetry Codon position Gradient Strand-biased gene distribution Poic |
| ISSN号 | 0923-2508 |
| DOI | 10.1016/j.resmic.2010.09.015 |
| 通讯作者 | Yu, jun(jun.yu@kaust.edu.sa) |
| 英文摘要 | Nucleotide compositional asymmetry (nca) between leading and lagging strands (les and las) is dynamic and diverse among eubacterial genomes due to different mutation and selection forces. a thorough investigation is needed in order to study the relationship between nucleotide composition dynamics and gene distribution biases. based on a collection of 364 eubacterial genomes that were grouped according to a dnae-based scheme (dnae1-dnae1, dnae2-dnae1, and dnae3-polc), we investigated nca and nucleotide composition gradients at three codon positions and found that there was universal g-enrichment on les among all groups. this was due to a strong selection for g-heading (codon position1 or cp 1) codons and mutation pressure that led to more g-ending (cp3) codons. moreover, a slight t-enrichment of les due to the mutation of cytosine deamination at cp3 was universal among dnae1-dnae1 and dnae2-dnae1 genomes, but was not clearly seen among dnae3-polc genomes, in which a-enrichment of les was proposed to be the effect of selections unique to polc and a mutation bias toward a-richness at cp i that may be a result of transcription-coupled dna repair mechanisms. furthermore, strand-biased gene distribution enhances the purine-richness of les for dnae3-polc genomes and t-richness of les for dnae1-dnae1 and dnae2-dnae1 genomes. (c) 2010 institut pasteur. published by elsevier masson sas. all rights reserved. |
| WOS关键词 | CODON USAGE ; GENETIC-CODE ; SUBSTITUTION PATTERNS ; PROKARYOTIC GENOMES ; ERROR MINIMIZATION ; MUTATIONAL BIASES ; BACTERIAL GENOMES ; ESCHERICHIA-COLI ; REPLICATION FORK ; DNA |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000286156800006 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2405821 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Jun |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100094, Peoples R China 3.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310007, Zhejiang, Peoples R China 4.King Abdullah Univ Sci & Technol, Div Chem & Life Sci & Engn, Plant Stress Genom Res Ctr, Thuwal 239556900, Saudi Arabia |
| 推荐引用方式 GB/T 7714 | Qu, Hongzhu,Wu, Hao,Zhang, Tongwu,et al. Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes[J]. Research in microbiology,2010,161(10):838-846. |
| APA | Qu, Hongzhu,Wu, Hao,Zhang, Tongwu,Zhang, Zhang,Hu, Songnian,&Yu, Jun.(2010).Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes.Research in microbiology,161(10),838-846. |
| MLA | Qu, Hongzhu,et al."Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes".Research in microbiology 161.10(2010):838-846. |
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