QQ客服 官方微博 反馈留言

	Human transcriptional interactome of chromatin contribute to gene co-expression
	Dong, Xiao1,2; Li, Chao1,2,3; Chen, Yunqin4; Ding, Guohui1,5; Li, Yixue1,5
刊名	Bmc genomics
	2010-12-14
卷号	11页码:5
ISSN号	1471-2164
DOI	10.1186/1471-2164-11-704
通讯作者	Ding, guohui(gwding@sibs.ac.cn)
英文摘要	Background: transcriptional interactome of chromatin is one of the important mechanisms in gene transcription regulation. by chromatin conformation capture and 3d fish experiments, several chromatin interactions cases among sequence-distant genes or even inter-chromatin genes were reported. however, on genomics level, there is still little evidence to support these mechanisms. recently based on hi-c experiment, a genome-wide picture of chromatin interactions in human cells was presented. it provides a useful material for analysing whether the mechanism of transcriptional interactome is common. results: the main work here is to demonstrate whether the effects of transcriptional interactome on gene co-expression exist on genomic level. while controlling the effects of transcription factors control similarities (tcs), we tested the correlation between hi-c interaction and the mutual ranks of gene co-expression rates (provided by coxpresdb) of intra-chromatin gene pairs. we used 6,084 genes with both tf annotation and co-expression information, and matched them into 273,458 pairs with similar hi-c interaction ranks in different cell types. the results illustrate that co-expression is strongly associated with chromatin interaction. further analysis using go annotation reveals potential correlation between gene function similarity, hi-c interaction and their co-expression. conclusions: according to the results in this research, the intra-chromatin interactome may have relation to gene function and associate with co-expression. this study provides evidence for illustrating the effect of transcriptional interactome on transcription regulation.
WOS关键词	CHROMOSOME CONFORMATION ; NUCLEAR-ORGANIZATION ; SEMANTIC SIMILARITY ; GO TERMS ; GENOME ; ASSOCIATION ; EXPRESSION ; SPECKLES ; DOMAINS
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	BIOMED CENTRAL LTD
WOS记录号	WOS:000285582200001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2405601
专题	中国科学院大学
通讯作者	Ding, Guohui
作者单位	1.Chinese Acad Sci, Key Lab Syst Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China 4.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China 5.Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Dong, Xiao,Li, Chao,Chen, Yunqin,et al. Human transcriptional interactome of chromatin contribute to gene co-expression[J]. Bmc genomics,2010,11:5.
APA	Dong, Xiao,Li, Chao,Chen, Yunqin,Ding, Guohui,&Li, Yixue.(2010).Human transcriptional interactome of chromatin contribute to gene co-expression.Bmc genomics,11,5.
MLA	Dong, Xiao,et al."Human transcriptional interactome of chromatin contribute to gene co-expression".Bmc genomics 11(2010):5.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。