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	Identification of blys (b lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for nogo-66 receptor
	Zhang, Lei1,2; Zheng, Sushuang1; Wu, Haitao3; Wu, Yan3; Liu, Shuhong3; Fan, Ming3; Zhang, Jian1
刊名	Journal of neuroscience
	2009-05-13
卷号	29期号:19页码:6348-6352
ISSN号	0270-6474
DOI	10.1523/jneurosci.5040-08.2009
通讯作者	Zhang, jian(jianzhang84@genetics.ac.cn)
英文摘要	B lymphocyte stimulator (blys), a tumor necrosis factor family protein essential for b cell development, was previously shown to be expressed at an elevated level in the cns of multiple sclerosis patients. although it may be involved in cns diseases, its exact functions in cns remain unknown. we hypothesize that blys may be a negative regulator for neuronal functions. here nogo-66 receptor (ngr) is identified as a high affinity receptor for blys, which inhibits dorsal root ganglion outgrowth in culture. the inhibition by blys can be reversed by a truncated ngr or by removal of glycosylphosphatidylinositol-linked proteins from neurons. more importantly, the inhibitory effect by blys is significantly diminished for neurons isolated from ngr(-/-) mice. furthermore, expressions of blys and ngr are also found to be associated with astrocytes and macrophages/microglial cells at spinal cord injury sites. thus, blys can function independently of myelin-associated inhibitors and likely serves as a redundant ngr ligand that negatively influences axonal outgrowth in cns.
WOS关键词	SPINAL-CORD-INJURY ; MULTIPLE-SCLEROSIS ; AXON REGENERATION ; INHIBITION ; EXPRESSION ; RECOVERY ; GROWTH ; BAFF ; DEGENERATION ; ASTROCYTES
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:000266042700031
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2403586
专题	中国科学院大学
通讯作者	Zhang, Jian
作者单位	1.Chinese Acad Sci, Mol & Dev Biol Lab, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Inst Basic Med Sci, Dept Neurophysiol, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lei,Zheng, Sushuang,Wu, Haitao,et al. Identification of blys (b lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for nogo-66 receptor[J]. Journal of neuroscience,2009,29(19):6348-6352.
APA	Zhang, Lei.,Zheng, Sushuang.,Wu, Haitao.,Wu, Yan.,Liu, Shuhong.,...&Zhang, Jian.(2009).Identification of blys (b lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for nogo-66 receptor.Journal of neuroscience,29(19),6348-6352.
MLA	Zhang, Lei,et al."Identification of blys (b lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for nogo-66 receptor".Journal of neuroscience 29.19(2009):6348-6352.

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